Description
Human PPARGC1A Recombinant Protein (N-His)
Human PPARGC1A Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Ser636-Arg798, with an N-terminal His tag. Predicted molecular weight: 22.11 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A) is a ~91 kDa protein. Transcriptional coactivator for steroid receptors and nuclear receptors. For research use only.
Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Acts as a key regulator of gluconeogenesis: stimulates hepatic gluconeogenesis by increasing the expression of gluconeogenic enzymes, and acting together with FOXO1 to promote the fasting gluconeogenic program.
| Product Name: | Human PPARGC1A Recombinant Protein (N-His) |
| SKU: | GXRP04121 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | LEM6, PGC1A, PPARGC1, Ligand effect modulator 6, PGC-1-alpha, PPAR-gamma coactivator 1-alpha, Peroxisome proliferator-activated receptor gamma coactivator 1-alpha, PPARGC-1-alpha, PPARGC1A, PGC1 |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Ser636-Arg798 |
| Calculated MW: | 22.11 kDa |
| UniProt: | Q9UBK2 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only. |
