Description
Human PRDM1 Recombinant Protein (N-His)
Human PRDM1 Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning His493-Lys678, with an N-terminal His tag. Predicted molecular weight: 22.82 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. PR domain zinc finger protein 1 (PRDM1) is a ~91 kDa protein. Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. For research use only.
Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection. Binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells. Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions.
| Product Name: | Human PRDM1 Recombinant Protein (N-His) |
| SKU: | GXRP00252 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | BLIMP-1, PRDI-BF1, PRDI-binding factor 1, BLIMP1, Positive regulatory domain I-binding factor 1, Beta-interferon gene positive regulatory domain I-binding factor, PR domain-containing protein 1, PR domain zinc finger protein 1, PRDM1 |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | His493-Lys678 |
| Calculated MW: | 22.82 kDa |
| UniProt: | O75626 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only. |
