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Human PTPRS Recombinant Protein (N-His)
Key Features

Human PTPRS Recombinant Protein (N-His) (GXRP02189)

SKU GXRP02189
Product Type Recombinant Protein
Species Human
Expression System E. coli
Tag N-His
$458 - $2,412

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Description

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Human PTPRS Recombinant Protein (N-His)

Human PTPRS Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Arg77-Gly374, with an N-terminal His tag. Predicted molecular weight: 34.99 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Receptor-type tyrosine-protein phosphatase S (PTPRS) is a ~217 kDa protein. Cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycan. For research use only.

Binding to chondroitin sulfate and heparan sulfate proteoglycans has opposite effects on PTPRS oligomerization and regulation of neurite outgrowth. Contributes to the inhibition of neurite and axonal outgrowth by chondroitin sulfate proteoglycans, also after nerve transection. Plays a role in stimulating neurite outgrowth in response to the heparan sulfate proteoglycan GPC2. Required for normal brain development, especially for normal development of the pituitary gland and the olfactory bulb.

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