Description
Human RUVBL1 Recombinant Protein (N-His)
Human RUVBL1 Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Met1-Lys456, with an N-terminal His tag. Predicted molecular weight: 52.39 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. RuvB-like 1 (RUVBL1) is a ~50 kDa protein. Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity. For research use only.
Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400.
| Product Name: | Human RUVBL1 Recombinant Protein (N-His) |
| SKU: | GXRP03521 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | 49 kDa TBP-interacting protein, Nuclear matrix protein 238, NMP 238, TAP54-alpha, RuvB-like 1, INO80H, 54 kDa erythrocyte cytosolic protein, TIP60-associated protein 54-alpha, 49 kDa TATA box-binding protein-interacting protein, RUVBL1, Pontin 52, TIP49, INO80 complex subunit H, ECP-54, TIP49A, NMP238, TIP49a |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Met1-Lys456 |
| Calculated MW: | 52.39 kDa |
| UniProt: | Q9Y265 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only. |
