Human sCD23 Recombinant Protein (RPPB3035)
- SKU:
- RPPB3035
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P06734
- Research Area:
- CD Antigens
Frequently bought together:
Description
| Product Name: | Human sCD23 Recombinant Protein |
| Product Code: | RPPB3035 |
| Size: | 20µg |
| Species: | Human |
| Target: | sCD23 |
| Synonyms: | Low affinity immunoglobulin epsilon Fc receptor, Lymphocyte IgE receptor, Fc-epsilon-RII, BLAST-2, Immunoglobulin E-binding factor, CD23 antigen, FCER2, CD23, FCE2, CD23A, IGEBF, CLEC4J. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | Lyophilized from a 0.2�m filtered concentrated solution in PBS, pH 7.4. |
| Solubility: | It is recommended to reconstitute the lyophilized sCD23 in sterile 18M-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized sCD23 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution sCD23 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. |
| Purity: | Greater than 97.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE. |
| Amino Acid Sequence: | MELQVSSGFV CNTCPEKWIN FQRKCYYFGK GTKQWVHARY ACDDMEGQLV SIHSPEEQDF LTKHASHTGS WIGLRNLDLK GEFIWVDGSH VDYSNWAPGE PTSRSQGEDC VMMRGSGRWN DAFCDRKLGA WVCDRLATCT PPASEGSAES MGPDSRPDPD GRLPTPSAPL HS� |
| Biological Activity: | The ED50 is determined by its ability to induce TNF-alpha production by human PBMCs.� |
CD23 is a 45kDa glycoprotein, which is present on a subpopulation of freshly isolated peripheral blood and tonsil B cells and strongly expressed on EBV-transformed B lymphoblasts. The CD23 molecule is identical to the low affinity IgE receptor found on B cells. Expression of CD23 has been detected in neoplastic cells from cases of B cell chronic lymphocyctic leukaemia and some cases of centroblastic/centrocytic lymphoma.
sCD23 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 172 amino acids and having a molecular mass of 19.2kDa.The sCD23 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen). |
| NCBI Summary: | The protein encoded by this gene is a B-cell specific antigen, and a low-affinity receptor for IgE. It has essential roles in B cell growth and differentiation, and the regulation of IgE production. This protein also exists as a soluble secreted form, then functioning as a potent mitogenic growth factor. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011] |
| UniProt Code: | P06734 |
| NCBI GenInfo Identifier: | 119862 |
| NCBI Gene ID: | 2208 |
| NCBI Accession: | P06734.1 |
| UniProt Related Accession: | P06734 |
| Molecular Weight: | |
| NCBI Full Name: | Low affinity immunoglobulin epsilon Fc receptor |
| NCBI Synonym Full Names: | Fc fragment of IgE receptor II |
| NCBI Official Symbol: | FCER2�� |
| NCBI Official Synonym Symbols: | CD23; FCE2; CD23A; IGEBF; CLEC4J; BLAST-2�� |
| NCBI Protein Information: | low affinity immunoglobulin epsilon Fc receptor |
| UniProt Protein Name: | Low affinity immunoglobulin epsilon Fc receptor |
| UniProt Synonym Protein Names: | BLAST-2; C-type lectin domain family 4 member J; Fc-epsilon-RII; Immunoglobulin E-binding factor; Lymphocyte IgE receptor; CD_antigen: CD23Cleaved into the following 2 chains:Low affinity immunoglobulin epsilon Fc receptor membrane-bound form; Low affinity immunoglobulin epsilon Fc receptor soluble form |
| UniProt Gene Name: | FCER2�� |
| UniProt Entry Name: | FCER2_HUMAN |
