Description
Human SCUBE3 Recombinant Protein (N-His)
Human SCUBE3 Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Glu807-Lys993, with an N-terminal His tag. Predicted molecular weight: 24.12 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Signal peptide, CUB and EGF-like domain-containing protein 3 (SCUBE3) is a ~109 kDa protein. Is a positive regulator of the BMP signaling pathway, required for proper chondrogenesis, osteogenesis and skeletal development. For research use only.
It acts as a coreceptor for BMP ligands, particularly BMP2 and BMP4, facilitating their interactions with BMP type I receptors. It is required for ligand-induced recruitment of BMP receptors to lipid rafts. Binds to TGFBR2 and activates TGFB signaling. In lung cancer cells, could serve as an endogenous autocrine and paracrine ligand of TGFBR2, which could regulate TGFBR2 signaling and hence modulate epithelial-mesenchymal transition and cancer progression.
| Product Name: | Human SCUBE3 Recombinant Protein (N-His) |
| SKU: | GXRP02550 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | Signal peptide, CUB and EGF-like domain-containing protein 3, CEGF3, SCUBE3 |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Glu807-Lys993 |
| Calculated MW: | 24.12 kDa |
| UniProt: | Q8IX30 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only. |
