Description
Human SLC22A6 Recombinant Protein (N-His-SUMO)
Human SLC22A6 Recombinant Protein (N-His-SUMO) is a recombinant protein expressed in E. coli, spanning Thr41-Arg131, with an N-terminal His-SUMO tag. Predicted molecular weight: 22.34 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Solute carrier family 22 member 6 (SLC22A6) is a ~61 kDa protein. Secondary active transporter that functions as a Na(+)-independent organic anion (OA)/dicarboxylate antiporter where the uptake of one molecule of OA into the cell is coupled with an efflux of one molecule of intracellular dicarboxylate such as 2-oxoglutarate or glutarate. For research use only.
Mediates the uptake of OA across the basolateral side of proximal tubule epithelial cells, thereby contributing to the renal elimination of endogenous OA from the systemic circulation into the urine. Functions as a biopterin transporters involved in the uptake and the secretion of coenzymes tetrahydrobiopterin (BH4), dihydrobiopterin (BH2) and sepiapterin to urine, thereby determining baseline levels of blood biopterins. Transports prostaglandin E2 (PGE2) and prostaglandin F2-alpha (PGF2-alpha) and may contribute to their renal excretion. Also mediates the uptake of cyclic nucleotides such as cAMP and cGMP.
| Product Name: | Human SLC22A6 Recombinant Protein (N-His-SUMO) |
| SKU: | GXRP04662 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | hROAT1, PAH transporter, Solute carrier family 22 member 6, PAHT, Renal organic anion transporter 1, hPAHT, OAT1, SLC22A6, Organic anion transporter 1, hOAT1 |
| Tag: | N-His-SUMO |
| Expression Host: | E. coli |
| Protein Length: | Thr41-Arg131 |
| Calculated MW: | 22.34 kDa |
| UniProt: | Q4U2R8 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only. |
