Description
Human TGM2 Recombinant Protein (C-His)
Human TGM2 Recombinant Protein (C-His) is a recombinant protein expressed in mammalian cells, spanning Ala2-Ala687, with a C-terminal His tag. Predicted molecular weight: 80.16 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Protein-glutamine gamma-glutamyltransferase 2 (TGM2) is a ~77 kDa protein. Calcium-dependent acyltransferase that catalyzes the formation of covalent bonds between peptide-bound glutamine and various primary amines, such as gamma-amino group of peptide-bound lysine, or mono- and polyamines, thereby producing cross-linked or aminated proteins, respectively. For research use only.
Involved in many biological processes, such as bone development, angiogenesis, wound healing, cellular differentiation, chromatin modification and apoptosis. Acts as a protein-glutamine gamma-glutamyltransferase by mediating the cross-linking of proteins, such as ACO2, HSPB6, FN1, HMGB1, RAP1GDS1, SLC25A4/ANT1, SPP1 and WDR54. Under physiological conditions, the protein cross-linking activity is inhibited by GTP; inhibition is relieved by Ca(2+) in response to various stresses. When secreted, catalyzes cross-linking of proteins of the extracellular matrix, such as FN1 and SPP1 resulting in the formation of scaffolds.
| Product Name: | Human TGM2 Recombinant Protein (C-His) |
| SKU: | GXRP06000 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | Protein-glutamine gamma-glutamyltransferase 2, 2.3.2.13, Erythrocyte transglutaminase, Heart G alpha(h), hhG alpha(h), Isopeptidase TGM2, 3.4.-.-, Protein G alpha(h), G(h), Protein-glutamine deamidase TGM2, 3.5.1.44, Protein-glutamine dopaminyltransferase TGM2, 2.3.1.-, Protein-glutamine histaminyltransferase TGM2, 2.3.1.-, Protein-glutamine noradrenalinyltransferase TGM2, 2.3.1.-, Protein-glutamine serotonyltransferase TGM2, 2.3.1.-, Tissue transglutaminase, tTG, tTgase, Transglutaminase C, TG(C), TGC, TGase C, Transglutaminase H, TGase H, Transglutaminase II, TGase II, Transglutaminase-2, TG2, TGase-2, hTG2, TGM2 |
| Tag: | C-His |
| Expression Host: | Mammalian cells |
| Protein Length: | Ala2-Ala687 |
| Calculated MW: | 80.16 kDa |
| UniProt: | P21980 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only. |
