Description
Human TICAM1 Recombinant Protein (N-His)
Human TICAM1 Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Met1-Cys144, with an N-terminal His tag. Predicted molecular weight: 18.02 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. TIR domain-containing adapter molecule 1 is a ~76 kDa protein. Involved in innate immunity against invading pathogens. For research use only.
Adapter used by TLR3, TLR4 (through TICAM2) and TLR5 to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively. Phosphorylation by TBK1 on the pLxIS motif leads to recruitment and subsequent activation of the transcription factor IRF3 to induce expression of type I interferon and exert a potent immunity against invading pathogens.
| Product Name: | Human TICAM1 Recombinant Protein (N-His) |
| SKU: | GXRP12404 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | MyD88-3, PRVTIRB, Proline-rich, vinculin and TIR domain-containing protein B, Putative NF-kappa-B-activating protein 502H, TICAM-1, TICAM1, TIR domain-containing adapter molecule 1, TIR domain-containing adapter protein inducing IFN-beta, TRIF, Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Met1-Cys144 |
| Calculated MW: | 18.02 kDa |
| UniProt: | Q8IUC6 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only |
