Description
Human TMPRSS2 Recombinant Protein (N-His)
Human TMPRSS2 Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Met109-Gly492, with an N-terminal His tag. Predicted molecular weight: 44.52 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Transmembrane protease serine 2 (TMPRSS2) is a ~53 kDa protein. Plasma membrane-anchored serine protease that cleaves at arginine residues. For research use only.
Participates in proteolytic cascades of relevance for the normal physiologic function of the prostate. Androgen-induced TMPRSS2 activates several substrates that include pro-hepatocyte growth factor/HGF, the protease activated receptor-2/F2RL1 or matriptase/ST14 leading to extracellular matrix disruption and metastasis of prostate cancer cells. In addition, activates trigeminal neurons and contribute to both spontaneous pain and mechanical allodynia.
| Product Name: | Human TMPRSS2 Recombinant Protein (N-His) |
| SKU: | GXRP06010 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | Transmembrane protease serine 2, 3.4.21.122, Serine protease 10, Transmembrane protease serine 2 non-catalytic chain, Transmembrane protease serine 2 catalytic chain, TMPRSS2, PRSS10 |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Met109-Gly492 |
| Calculated MW: | 44.52 kDa |
| UniProt: | O15393 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only. |
