Description
Human TNFAIP3 Recombinant Protein (N-GST)
Human TNFAIP3 Recombinant Protein (N-GST) is a recombinant protein expressed in E. coli, spanning Met1-Gly790, with an N-terminal GST tag. Predicted molecular weight: 115.91 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Tumor necrosis factor alpha-induced protein 3 (TNFAIP3) is a ~89 kDa protein. Ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities. For research use only.
Involved in immune and inflammatory responses signaled by cytokines, such as TNF and IL-1 beta, or pathogens via Toll-like receptors (TLRs) through terminating NF-kappa-B activity. Essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. In cooperation with TAX1BP1 promotes disassembly of E2-E3 ubiquitin protein ligase complexes in IL-1R and TNFR-1 pathways; affected are at least E3 ligases TRAF6, TRAF2 and BIRC2, and E2 ubiquitin-conjugating enzymes UBE2N and UBE2D3. In cooperation with TAX1BP1 promotes ubiquitination of UBE2N and proteasomal degradation of UBE2N and UBE2D3.
| Product Name: | Human TNFAIP3 Recombinant Protein (N-GST) |
| SKU: | GXRP06996 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | Tumor necrosis factor alpha-induced protein 3, TNF alpha-induced protein 3, 2.3.2.-, 3.4.19.12, OTU domain-containing protein 7C, Putative DNA-binding protein A20, Zinc finger protein A20, A20p50, A20p37, TNFAIP3, OTUD7C |
| Tag: | N-GST |
| Expression Host: | E. coli |
| Protein Length: | Met1-Gly790 |
| Calculated MW: | 115.91 kDa |
| UniProt: | P21580 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only. |
