Description
Human TNIP2 Recombinant Protein (N-His)
Human TNIP2 Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Leu31-Glu184, with an N-terminal His tag. Predicted molecular weight: 20.01 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. TNFAIP3-interacting protein 2 (TNIP2) is a ~48 kDa protein. Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG. For research use only.
Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway during innate immune response; this function seems to be stimulus- and cell type specific. Required for stability of MAP3K8. Involved in regulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial survival.
| Product Name: | Human TNIP2 Recombinant Protein (N-His) |
| SKU: | GXRP02600 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | A20-binding inhibitor of NF-kappa-B activation 2, ABIN2, ABIN-2, FLIP1, TNFAIP3-interacting protein 2, TNIP2, Fetal liver LKB1-interacting protein |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Leu31-Glu184 |
| Calculated MW: | 20.01 kDa |
| UniProt: | Q8NFZ5 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only. |
