Description
Human TRIM21/RO52 Recombinant Protein
Human TRIM21/RO52 Recombinant Protein is a recombinant protein expressed in confidential, spanning Confidential. Predicted molecular weight: 56.33 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. E3 ubiquitin-protein ligase TRIM21 is a ~54 kDa protein. E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. For research use only.
Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of USP4 and IKBKB but also for its self-ubiquitination. Component of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes. A TRIM21-containing SCF(SKP2)-like complex is shown to mediate ubiquitination of CDKN1B ('Thr-187' phosphorylated-form), thereby promoting its degradation by the proteasome. Monoubiquitinates IKBKB that will negatively regulates Tax-induced NF-kappa-B signaling.
| Product Name: | Human TRIM21/RO52 Recombinant Protein |
| SKU: | GXRP03563 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | SS-A, E3 ubiquitin-protein ligase TRIM21, TRIM21, Ro(SS-A), 52 kDa Ro protein, Tripartite motif-containing protein 21, RING finger protein 81, 52 kDa ribonucleoprotein autoantigen Ro/SS-A, RNF81, Sjoegren syndrome type A antigen, RO52, RING-type E3 ubiquitin transferase TRIM21, SSA1 |
| Expression Host: | Confidential |
| Protein Length: | Confidential |
| Calculated MW: | 56.33 kDa |
| UniProt: | P19474 |
| Applications: | As a diagnostic tool for Systemic Lupus Erythematosus (SLE) and Sjögren Syndrome (SS). |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only. |
