Human TSHB Recombinant Protein (RPPB1308)
- SKU:
- RPPB1308
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P01222
- Research Area:
- Hormones
Description
| Product Name: | Human TSHB Recombinant Protein |
| Product Code: | RPPB1308 |
| Size: | 10µg |
| Species: | Human |
| Target: | TSHB |
| Synonyms: | TSHB |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | TSHB protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 0.4M Urea and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze thaw cycles. |
| Purity: | Greaterthan 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSFCIPTEY TMHIERRECA YCLTINTTIC AGYCMTRDIN GKLFLPKYAL SQDVCTYRDF IYRTVEIPGC PLHVAPYFSY PVALSCKCGK CNTDYSDCIH EAIKTNYCTK PQKSYLVGFS V |
TSHB is a hormone synthesized and secreted by thyrotrope cells in the anterior pituitary gland which regulates the endocrine function of the T gland. Stimulates the gland to secrete the hormones (T4) and triiodothyronine (T3). Production is controlled by a Thyrotropin Releasing Hormone, (TRH), which is manufactured in the hypothalamus and transported to the Anterior Pituitary gland, where it increases production and release. Somatostatin is also produced by the hypothalamus, and has an opposite effect on the pituitary production, decreasing or inhibiting its release. The level of T�hormones (T3 and T4) in the blood have an additional effect on the pituitary release of TSH, When the levels of T3 and T4 are low, the production is increased, and conversely, when levels of T3 and T4 are high, then production is decreased. This effect creates a regulatory negative feedback loop.
TSHB Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 141 amino acids (21-138 a.a) and having a molecular mass of 15.9kDa.TSHB is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | TSHB: Indispensable for the control of thyroid structure and metabolism. Belongs to the glycoprotein hormones subunit beta family. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 1p13 Cellular Component: extracellular region Molecular Function:hormone activity Biological Process: G-protein coupled receptor protein signaling pathway; anatomical structure morphogenesis; cellular protein metabolic process; cell-cell signaling; response to estrogen stimulus; peptide hormone processing; response to calcium ion; response to vitamin A Disease: Hypothyroidism, Congenital, Nongoitrous, 4 |
| NCBI Summary: | The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. Thyroid stimulating hormone functions in the control of thyroid structure and metabolism. The protein encoded by this gene is the beta subunit of thyroid stimulating hormone. Mutations in this gene are associated with congenital central and secondary hypothyroidism and Hashimoto's thyroiditis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013] |
| UniProt Code: | P01222 |
| NCBI GenInfo Identifier: | 311033515 |
| NCBI Gene ID: | 7252 |
| NCBI Accession: | P01222.2 |
| UniProt Secondary Accession: | P01222,Q16163, B1AKP0, |
| UniProt Related Accession: | P01222 |
| Molecular Weight: | 138 |
| NCBI Full Name: | Thyrotropin subunit beta |
| NCBI Synonym Full Names: | thyroid stimulating hormone, beta |
| NCBI Official Symbol: | TSHB�� |
| NCBI Official Synonym Symbols: | TSH-B; TSH-BETA�� |
| NCBI Protein Information: | thyrotropin subunit beta; thyrotropin beta chain |
| UniProt Protein Name: | Thyrotropin subunit beta |
| UniProt Synonym Protein Names: | Thyroid-stimulating hormone subunit beta; TSH-B; TSH-beta; Thyrotropin beta chain; INN: Thyrotropin alfa |
| Protein Family: | Thyrotropin |
| UniProt Gene Name: | TSHB�� |
| UniProt Entry Name: | TSHB_HUMAN |
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