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Human TSPAN15 Recombinant Protein (N-His)
Key Features

Human TSPAN15 Recombinant Protein (N-His) (GXRP07482)

SKU GXRP07482
Product Type Recombinant Protein
Species Human
Expression System E. coli
Tag N-His
$458 - $2,412

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Description

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Human TSPAN15 Recombinant Protein (N-His)

Human TSPAN15 Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Thr115-Ala235, with an N-terminal His tag. Predicted molecular weight: 16.46 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Tetraspanin-15 (TSPAN15) is a ~33 kDa protein. Part of TspanC8 subgroup, composed of 6 members that interact with the transmembrane metalloprotease ADAM10. For research use only.

This interaction is required for ADAM10 exit from the endoplasmic reticulum and for enzymatic maturation and trafficking to the cell surface as well as substrate specificity. Different TspanC8/ADAM10 complexes have distinct substrates. Promotes ADAM10-mediated cleavage of CDH2. Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity.

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