Description
Human UFD1 Recombinant Protein (N-His)
Human UFD1 Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Arg18-Asp192, with an N-terminal His tag. Predicted molecular weight: 22.10 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Ubiquitin recognition factor in ER-associated degradation protein 1 (UFD1) is a ~34 kDa protein. Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. For research use only.
The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-derived structures. Acts as a negative regulator of type I interferon production via the complex formed with VCP and NPLOC4, which binds to RIGI and recruits RNF125 to promote ubiquitination and degradation of RIGI.
| Product Name: | Human UFD1 Recombinant Protein (N-His) |
| SKU: | GXRP04404 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | UFD1L, Ubiquitin recognition factor in ER-associated degradation protein 1, UB fusion protein 1, UFD1, Ubiquitin fusion degradation protein 1 |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Arg18-Asp192 |
| Calculated MW: | 22.10 kDa |
| UniProt: | Q92890 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only. |
