Description
Human ULK3 Recombinant Protein (N-His)
Human ULK3 Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Met1-Pro276, with an N-terminal His tag. Predicted molecular weight: 34.10 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Serine/threonine-protein kinase ULK3 is a ~53 kDa protein. Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. For research use only.
Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy.
| Product Name: | Human ULK3 Recombinant Protein (N-His) |
| SKU: | GXRP11619 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | EC:2.7.11.1, Serine/threonine-protein kinase ULK3, ULK3, Unc-51-like kinase 3 |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Met1-Pro276 |
| Calculated MW: | 34.10 kDa |
| UniProt: | Q6PHR2 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only |
