Description
Human USP17L2 Recombinant Protein (N-His)
Human USP17L2 Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Ala76-Gly388, with an N-terminal His tag. Predicted molecular weight: 37.32 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Ubiquitin carboxyl-terminal hydrolase 17 is a ~59 kDa protein. Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. For research use only.
Regulates cell proliferation by deubiquitinating and inhibiting RCE1 thereby controlling the small GTPases NRAS and HRAS localization and activation. In parallel, mediates deubiquitination of CDC25A, preventing CDC25A degradation by the proteasome during the G1/S and G2/M phases promoting cell-cycle progression. Also regulates cell proliferation and apoptosis through deubiquitination of SUDS3 a regulator of histone deacetylation. Through activation of the Rho family GTPases RAC1A, CDC42 and RHOA, regulates cell migration.
| Product Name: | Human USP17L2 Recombinant Protein (N-His) |
| SKU: | GXRP11629 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | DUB-3, DUB3, Deubiquitinating enzyme 17-like protein 2, Deubiquitinating protein 3, EC:3.4.19.12, USP17, USP17H, USP17I, USP17J, USP17K, USP17L, USP17L2, USP17M, Ubiquitin carboxyl-terminal hydrolase 17, Ubiquitin carboxyl-terminal hydrolase 17-like protein 2, Ubiquitin thioesterase 17-like protein 2, Ubiquitin-specific-processing protease 17-like protein 2 |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Ala76-Gly388 |
| Calculated MW: | 37.32 kDa |
| UniProt: | Q6R6M4 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only |
