Description
Human USP51 Recombinant Protein (N-His)
Human USP51 Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Asn370-Asp711, with an N-terminal His tag. Predicted molecular weight: 41.09 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Ubiquitin carboxyl-terminal hydrolase 51 is a ~79 kDa protein. Specifically deubiquitinates 'Lys-14' (H2AK13Ub) and 'Lys-16'(H2AK15Ub) of histone H2A regulating the DNA damage response at double-strand breaks (DSBs). For research use only.
USP51 is recruited to chromatin after DNA damage and regulates the dynamic assembly/disassembly of TP53BP1 and BRCA1. Functions in DNA double-strand break repair also by mediating the deubiquitination and subsequent stabilization of DGCR8, leading to the recruitment of DGCR8 binding partners to double strand breaks such as RNF168 or MDC1. In addition, promotes the deubiquitination and stabilization of the transcriptional repressor ZEB1.
| Product Name: | Human USP51 Recombinant Protein (N-His) |
| SKU: | GXRP11276 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | Deubiquitinating enzyme 51, EC:3.4.19.12, USP51, Ubiquitin carboxyl-terminal hydrolase 51, Ubiquitin thioesterase 51, Ubiquitin-specific-processing protease 51 |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Asn370-Asp711 |
| Calculated MW: | 41.09 kDa |
| UniProt: | Q70EK9 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only |
