Description
Human WDR81 Recombinant Protein (N-His)
Human WDR81 Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Gly337-Gln614, with an N-terminal His tag. Predicted molecular weight: 34.14 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. WD repeat-containing protein 81 is a ~211 kDa protein. Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. For research use only.
By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport. It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome. May also play a role in aggrephagy, the macroautophagic degradation of ubiquitinated protein aggregates. In this process, may regulate the interaction of SQSTM1 with ubiquitinated proteins and also recruit MAP1LC3C.
| Product Name: | Human WDR81 Recombinant Protein (N-His) |
| SKU: | GXRP11558 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | WD repeat-containing protein 81, WDR81 |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Gly337-Gln614 |
| Calculated MW: | 34.14 kDa |
| UniProt: | Q562E7 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only |
