Description
Human WDR82 Recombinant Protein (N-His)
Human WDR82 Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Met1-Asp313, with an N-terminal His tag. Predicted molecular weight: 37.24 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. WD repeat-containing protein 82 is a ~35 kDa protein. Regulatory component of the SET1/COMPASS complex implicated in the tethering of this complex to transcriptional start sites of active genes. For research use only.
Facilitates histone H3 'Lys-4' methylation (H3K4me) via recruitment of the SETD1A or SETD1B to the 'Ser-5' phosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A). Component of the PNUTS-PP1 protein phosphatase complex, a protein phosphatase 1 (PP1) complex that promotes RNA polymerase II transcription pause-release, allowing transcription elongation. PNUTS-PP1 also plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Together with ZC3H4, but independently of the SET1 complex, part of a transcription termination checkpoint that promotes transcription termination of long non-coding RNAs (lncRNAs).
| Product Name: | Human WDR82 Recombinant Protein (N-His) |
| SKU: | GXRP09450 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | WD repeat-containing protein 82; WDR82; SWD2; TMEM113; WDR82A; UNQ9342/PRO34047 |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Met1-Asp313 |
| Calculated MW: | 37.24 kDa |
| UniProt: | Q6UXN9 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only |
