Description
Human YTHDF1 Recombinant Protein (N-His)
Human YTHDF1 Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning His365-Gln559, with an N-terminal His tag. Predicted molecular weight: 25.06 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. YTH domain-containing family protein 1 is a ~60 kDa protein. Specifically recognizes and binds N6-methyladenosine (m6A)-containing mRNAs, and regulates their stability. For research use only.
M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing. Acts as a regulator of mRNA stability by promoting degradation of m6A-containing mRNAs via interaction with the CCR4-NOT complex. The YTHDF paralogs (YTHDF1, YTHDF2 and YTHDF3) shares m6A-containing mRNAs targets and act redundantly to mediate mRNA degradation and cellular differentiation. Required to facilitate learning and memory formation in the hippocampus by binding to m6A-containing neuronal mRNAs.
| Product Name: | Human YTHDF1 Recombinant Protein (N-His) |
| SKU: | GXRP11077 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | C20orf21, DACA-1, DF1, Dermatomyositis associated with cancer putative autoantigen 1, YTH domain-containing family protein 1, YTHDF1 |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | His365-Gln559 |
| Calculated MW: | 25.06 kDa |
| UniProt: | Q9BYJ9 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only |
