UniProt Protein Function: | ICAM4: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM4 is also a ligand for alpha-4/beta-1 and alpha-V integrins. Belongs to the immunoglobulin superfamily. ICAM family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 19p13.2-cen Disease: Blood Group System, Landsteiner-wiener |
NCBI Summary: | This gene encodes the Landsteiner-Wiener (LW) blood group antigen(s) that belongs to the immunoglobulin (Ig) superfamily, and that shares similarity with the intercellular adhesion molecule (ICAM) protein family. This ICAM protein contains 2 Ig-like C2-type domains and binds to the leukocyte adhesion LFA-1 protein. The molecular basis of the LW(A)/LW(B) blood group antigens is a single aa variation at position 100; Gln-100=LW(A) and Arg-100=LW(B). Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q14773 |
NCBI GenInfo Identifier: | 2497309 |
NCBI Gene ID: | 3386 |
NCBI Accession: | Q14773.1 |
UniProt Secondary Accession: | Q14773,Q14771, Q14772, Q16375, Q9BWR0, A0M8X2, |
UniProt Related Accession: | Q14773 |
Molecular Weight: | 271 |
NCBI Full Name: | Intercellular adhesion molecule 4 |
NCBI Synonym Full Names: | intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) |
NCBI Official Symbol: | ICAM4Â Â |
NCBI Official Synonym Symbols: | LW; CD242Â Â |
NCBI Protein Information: | intercellular adhesion molecule 4; CD242 antigen; LW blood group protein; Landsteiner-Wiener blood group antigen a; Landsteiner-Wiener blood group glycoprotein; intercellular adhesion molecule 4 (LW blood group); intercellular adhesion molecule 4 isoform 3 anitgen LWa |
UniProt Protein Name: | Intercellular adhesion molecule 4 |
UniProt Synonym Protein Names: | Landsteiner-Wiener blood group glycoprotein; LW blood group protein; CD_antigen: CD242 |
Protein Family: | Intercellular adhesion molecule |
UniProt Gene Name: | ICAM4Â Â |
UniProt Entry Name: | ICAM4_HUMAN |