Anti-IFNL3 Antibody (CAB12908)

Antibody Name:	Anti-IFNL3 Antibody
Antibody SKU:	CAB12908
Antibody Size:	20uL, 50uL, 100uL
Application:	IHC IF
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 22-196 of human IFNL3 (NP_742151.2).

Application:	IHC IF
Recommended Dilution:	IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:	Human, Mouse, Rat
Positive Samples:

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 22-196 of human IFNL3 (NP_742151.2).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	VPVA RLRG ALPD ARGC HIAQ FKSL SPQE LQAF KRAK DALE ESLL LKDC KCRS RLFP RTWD LRQL QVRE RPVA LEAE LALT LKVL EATA DTDP ALGD VLDQ PLHT LHHI LSQL RACI QPQP TAGP RTRG RLHH WLHR LQEA PKKE SPGC LEAS VTFN LFRL LTRD LNCV ASGD LCV
Gene ID:	282617
Uniprot:	Q8IZI9
Cellular Location:	Secreted
Calculated MW:	21kDa
Observed MW:

Synonyms:

IFNL3, IFN-lambda-3, IFN-lambda-4, IL-28B, IL-28C, IL28B, IL28C

Background:

This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28A (IL28A), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA).

UniProt Protein Function:	IL-28B: Cytokine with immunomodulatory activity. Up-regulates MHC class I antigen expression. Displays potent antiviral activity. Also displays antitumor activity. Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IL28RA. The ligand/receptor complex seems to signal through the Jak-STAT pathway. Belongs to the IL-28/IL-29 family.
UniProt Protein Details:	Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 19q13.13 Cellular Component: extracellular space Molecular Function:cytokine activity Biological Process: positive regulation of immune response; negative regulation of viral genome replication; JAK-STAT cascade; defense response to virus Disease: Hepatitis C Virus, Susceptibility To
NCBI Summary:	This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28A (IL28A), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). [provided by RefSeq, Jul 2008]
UniProt Code:	Q8IZI9
NCBI GenInfo Identifier:	300669648
NCBI Gene ID:	282617
NCBI Accession:	Q8IZI9.2
UniProt Secondary Accession:	Q8IZI9,Q6VN56, Q7Z4J3, Q8IWL6, A2BDE1,
UniProt Related Accession:	Q8IZI9
Molecular Weight:	196
NCBI Full Name:	Interferon lambda-3
NCBI Synonym Full Names:	interferon, lambda 3
NCBI Official Symbol:	IFNL3
NCBI Official Synonym Symbols:	IL28B; IL28C; IL-28B
NCBI Protein Information:	interferon lambda-3; IL-28C; IFN-lambda-3; IFN-lambda-4; interleukin 28C; interleukin-28B; interleukin-28C; cytokine Zcyto22; interferon lambda-4; interferon, lambda 4; interleukin 28B (interferon, lambda 3)
UniProt Protein Name:	Interferon lambda-3
UniProt Synonym Protein Names:	Cytokine Zcyto22; Interleukin-28B; IL-28B; Interleukin-28C; IL-28C
Protein Family:	Interferon
UniProt Gene Name:	IFNL3
UniProt Entry Name:	IFNL3_HUMAN

	Immunohistochemistry of paraffin-embedded rat brain using IFNL3 antibody (CAB12908) at dilution of 1:100 (40x lens).
	Immunohistochemistry of paraffin-embedded human stomach using IFNL3 antibody (CAB12908) at dilution of 1:100 (40x lens).
	Immunohistochemistry of paraffin-embedded human gastric cancer using IFNL3 antibody (CAB12908) at dilution of 1:100 (40x lens).
	Immunohistochemistry of paraffin-embedded mouse lung using IFNL3 antibody (CAB12908) at dilution of 1:100 (40x lens).
	Immunofluorescence analysis of U2OS cells using IFNL3 antibody (CAB12908) at dilution of 1:100. Blue: DAPI for nuclear staining.

Antibodies	ELISA Kits
Anti-IFNL3 Antibody (CAB5648)	Human IL-28B / IL-28 beta ELISA Kit
	Human IL-28B ELISA Kit

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)