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Anti-IFT57 Antibody (CAB14652)

SKU:
CAB14652
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Death
  • Cell Death Antibodies 1 Anti-IFT57 Antibody CAB14652
  • Cell Death Antibodies 1 Anti-IFT57 Antibody CAB14652
€139 - €419
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-IFT57 Antibody
Antibody SKU:CAB14652
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 170-429 of human IFT57 (NP_060480.1).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 170-429 of human IFT57 (NP_060480.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:VEEL EEES VAED DAEL TLNK VDEE FVEE ETDN EENF IDLN VLKA QTYH LDMN ETAK QEDI LEST TDAA EWSL EVER VLPQ LKVT IRTD NKDW RIHV DQMH QHRS GIES ALKE TKGF LDKL HNEI TRTL EKIS SREK YINN QLEN LVQE YRAA QAQL SEAK ERYQ QGNG GVTE RTRL LSEV MEEL EKVK QEME EKGS SMTD GAPL VKIK QSLT KLKQ ETVE MDIR IGIV EHTL LQSK LKEK SNMT RNMH ATVI PEPA TGFY
Gene ID:55081
Uniprot:Q9NWB7
Cellular Location:Cytoplasm, cilium basal body, cytoskeleton
Calculated MW:49kDa
Observed MW:Refer to figures
Synonyms:IFT57, ESRRBL1, HIPPI, MHS4R2
Background:
UniProt Protein Function:IFT57: Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway. Has pro- apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear. Belongs to the IFT57 family.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 3q13.13

Cellular Component: Golgi apparatus; centrosome; photoreceptor connecting cilium; cilium

Molecular Function:protein binding; DNA binding

Biological Process: regulation of apoptosis; caspase activation; smoothened signaling pathway; regulation of transcription, DNA-dependent; transcription, DNA-dependent; apoptosis; organelle organization and biogenesis; neural tube closure; intraflagellar transport; cilium biogenesis; heart looping; negative regulation of epithelial cell proliferation

UniProt Code:Q9NWB7
NCBI GenInfo Identifier:74734638
NCBI Gene ID:55081
NCBI Accession:Q9NWB7.1
UniProt Secondary Accession:Q9NWB7,Q96DA9,
UniProt Related Accession:Q9NWB7
Molecular Weight:429
NCBI Full Name:Intraflagellar transport protein 57 homolog
NCBI Synonym Full Names:intraflagellar transport 57
NCBI Official Symbol:IFT57  
NCBI Official Synonym Symbols:HIPPI; MHS4R2; ESRRBL1  
NCBI Protein Information:intraflagellar transport protein 57 homolog; HIP1 protein interactor; HIP1-interacting protein; dermal papilla-derived protein 8; intraflagellar transport 57 homolog; estrogen-related receptor beta like 1; estrogen-related receptor beta-like protein 1; huntingtin interacting protein-1 interacting protein
UniProt Protein Name:Intraflagellar transport protein 57 homolog
UniProt Synonym Protein Names:Dermal papilla-derived protein 8; Estrogen-related receptor beta-like protein 1; HIP1-interacting protein; MHS4R2
Protein Family:Intraflagellar transport protein
UniProt Gene Name:IFT57  
UniProt Entry Name:IFT57_HUMAN
Anti-IFT57 Antibody (CAB14652)Immunohistochemistry of paraffin-embedded human uterine cancer using IFT57 antibody (CAB14652) at dilution of 1:100 (40x lens).
Anti-IFT57 Antibody (CAB14652)Immunohistochemistry of paraffin-embedded rat ovary using IFT57 antibody (CAB14652) at dilution of 1:100 (40x lens).

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