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Anti-IGF2BP2 Antibody (CAB14103)

SKU:
CAB14103
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling
  • Epigenetics and Nuclear Signaling Antibodies 3 Anti-IGF2BP2 Antibody CAB14103
  • Epigenetics and Nuclear Signaling Antibodies 3 Anti-IGF2BP2 Antibody CAB14103
€139 - €419
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Description

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Antibody Name:Anti-IGF2BP2 Antibody
Antibody SKU:CAB14103
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 500 to the C-terminus of human IGF2BP2 (NP_006539.3).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa, Jurkat, Mouse testis, Mouse ovary, Rat testis
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 500 to the C-terminus of human IGF2BP2 (NP_006539.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:NFFN PKEE VKLE AHIR VPSS TAGR VIGK GGKT VNEL QNLT SAEV IVPR DQTP DENE EVIV RIIG HFFA SQTA QRKI REIV QQVK QQEQ KYPQ GVAS QRSK
Gene ID:10644
Uniprot:Q9Y6M1
Cellular Location:Cytoplasm, Nucleus
Calculated MW:54kDa/58kDa/59kDa/61kDa/66kDa
Observed MW:70kDa
Synonyms:IGF2BP2, IMP-2, IMP2, VICKZ2
Background:This gene encodes a member of the IGF-II mRNA-binding protein (IMP) family. The protein encoded by this gene contains four KH domains and two RRM domains. It functions by binding to the 5' UTR of the insulin-like growth factor 2 (IGF2) mRNA and regulating IGF2 translation. Alternative promoter usage and alternate splicing result in multiple variants encoding different isoforms.
UniProt Protein Function:IGF2BP2: Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. Binding is isoform-specific. May regulate translation of target mRNAs. Belongs to the RRM IMP/VICKZ family. 6 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:RNA-binding; Translation

Chromosomal Location of Human Ortholog: 3q27.2

Cellular Component: cytoskeleton; cytoplasm; nucleus; cytosol

Molecular Function:protein binding; mRNA 3'-UTR binding; nucleotide binding; translation regulator activity; mRNA 5'-UTR binding

Biological Process: anatomical structure morphogenesis; mRNA transport; negative regulation of translation; gene expression; regulation of cytokine biosynthetic process

Disease: Diabetes Mellitus, Noninsulin-dependent

NCBI Summary:This gene encodes a member of the IGF-II mRNA-binding protein (IMP) family. The protein encoded by this gene contains four KH domains and two RRM domains. It functions by binding to the 5' UTR of the insulin-like growth factor 2 (IGF2) mRNA and regulating IGF2 translation. Alternative promoter usage and alternate splicing result in multiple variants encoding different isoforms. [provided by RefSeq, May 2014]
UniProt Code:Q9Y6M1
NCBI GenInfo Identifier:224471831
NCBI Gene ID:10644
NCBI Accession:Q9Y6M1.2
UniProt Secondary Accession:Q9Y6M1,A0A4Z0, B3FTN2, B3FTN3, B3FTN4,
UniProt Related Accession:Q9Y6M1
Molecular Weight:599
NCBI Full Name:Insulin-like growth factor 2 mRNA-binding protein 2
NCBI Synonym Full Names:insulin-like growth factor 2 mRNA binding protein 2
NCBI Official Symbol:IGF2BP2  
NCBI Official Synonym Symbols:IMP2; IMP-2; VICKZ2  
NCBI Protein Information:insulin-like growth factor 2 mRNA-binding protein 2; VICKZ family member 2; IGF2 mRNA-binding protein 2; IGF-II mRNA-binding protein 2
UniProt Protein Name:Insulin-like growth factor 2 mRNA-binding protein 2
UniProt Synonym Protein Names:Hepatocellular carcinoma autoantigen p62; IGF-II mRNA-binding protein 2; VICKZ family member 2
Protein Family:Insulin-like growth factor 2 mRNA-binding protein
UniProt Gene Name:IGF2BP2  
UniProt Entry Name:IF2B2_HUMAN
Anti-IGF2BP2 Antibody (CAB14103)Western blot analysis of extracts of various cell lines, using IGF2BP2 antibody (CAB14103) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 10s.
Anti-IGF2BP2 Antibody (CAB14103)Immunofluorescence analysis of U2OS cells using IGF2BP2 antibody (CAB14103) at dilution of 1:100. Blue: DAPI for nuclear staining.

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