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Anti-IL13RA2 Antibody (CAB19318)

SKU:
CAB19318
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
IL13RA2
CD213A2
CT19
IL-13R
IL13BP
Research Area:
Cell Biology
€139 - €419
Frequently bought together:

Description

Product Name:IL13RA2 Rabbit pAb
Product Code:CAB19318
Size:20uL, 50uL, 100uL
Synonyms:IL13RA2, CD213A2, CT19, IL-13R, IL13BP
Applications:WB, IHC, IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant protein of human IL13RA2.
Applications:WB, IHC, IF
Recommended Dilutions:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:A-549, PC-3, Rat liver
Immunogen:Recombinant protein of human IL13RA2.
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:3598
Uniprot:Q14627
Cellular Location:Membrane, Single-pass type I membrane protein
Calculated MW:44kDa
Observed MW:44kDa
UniProt Protein Function:IL13RA2: a type I membrane protein that binds with high affinity to interleukin-13 (IL13), but not to interleukin-4 (IL4). Lacks a cytoplasmic domain, and does not appear to function as a signal mediator. It is reported to play a role in the internalization of IL13. A member of the Cancer-Testis Antigen (CTA) superfamily. CTAs may play roles in embryonal development and tumor transformation or aspects of tumor progression. CTAs were once thought to be silenced in most normal adult tissues, with limited expression in fetal, placental, testis, and ovarian cells. These proteins are now known to be aberrantly expressed in various cancers and many are capable of eliciting humoral and cellular immune responses. The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. The box 1 motif is required for JAK interaction and/or activation. Often overexpressed in brain tumors. A potential vaccine targets for immunotherapy of glioma. Note: This description may include information from RefSeq and UniProtKB
UniProt Protein Details:

Protein type:Membrane protein, integral; Cancer Testis Antigen (CTA); Receptor, cytokine

Chromosomal Location of Human Ortholog: Xq23

Cellular Component: extracellular space; integral to membrane

Molecular Function:hematopoietin/interferon-class (D200-domain) cytokine receptor activity; signal transducer activity

Biological Process: cytokine and chemokine mediated signaling pathway; signal transduction

NCBI Summary:The protein encoded by this gene is closely related to Il13RA1, a subuint of the interleukin 13 receptor complex. This protein binds IL13 with high affinity, but lacks cytoplasmic domain, and does not appear to function as a signal mediator. It is reported to play a role in the internalization of IL13. [provided by RefSeq, Jul 2008]
UniProt Code:Q14627
NCBI GenInfo Identifier:2494720
NCBI Gene ID:3598
NCBI Accession:Q14627.1
UniProt Secondary Accession:Q14627,O00667, A8K7E2,
UniProt Related Accession:Q14627
Molecular Weight:380
NCBI Full Name:Interleukin-13 receptor subunit alpha-2
NCBI Synonym Full Names:interleukin 13 receptor, alpha 2
NCBI Official Symbol:IL13RA2  
NCBI Official Synonym Symbols:CT19; IL-13R; IL13BP; CD213A2  
NCBI Protein Information:interleukin-13 receptor subunit alpha-2; IL-13RA2; IL-13R-alpha-2; IL-13R subunit alpha-2; cancer/testis antigen 19; IL-13 receptor subunit alpha-2; interleukin 13 binding protein; interleukin-13-binding protein; interleukin 13 receptor alpha 2 chain
UniProt Protein Name:Interleukin-13 receptor subunit alpha-2
UniProt Synonym Protein Names:Interleukin-13-binding protein; CD_antigen: CD213a2
Protein Family:Interleukin-13 receptor
UniProt Gene Name:IL13RA2  
UniProt Entry Name:I13R2_HUMAN

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