Integrin alpha 2 Rabbit Monoclonal Antibody (CAB19068)

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SKU:
CAB19068
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Description

Technical Manual

Integrin alpha 2 Rabbit Monoclonal Antibody

Product Name:Integrin alpha 2 Rabbit Monoclonal Antibody
Product SKU:CAB19068
Size:20uL, 50 uL
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Background:

This gene encodes the alpha subunit of a transmembrane receptor for collagens and related proteins. The encoded protein forms a heterodimer with a beta subunit and mediates the adhesion of platelets and other cell types to the extracellular matrix. Loss of the encoded protein is associated with bleeding disorder platelet-type 9. Antibodies against this protein are found in several immune disorders, including neonatal alloimmune thrombocytopenia. This gene is located adjacent to a related alpha subunit gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

Immunogen:A synthesized peptide derived from human Integrin alpha 2
Sequence:

Email for sequence

Gene ID:3673
Swiss Prot:P17301
Synonyms:BR; CD49B; GPIa; HPA-5; VLA-2; VLAA2; ITGA2
Calculated MW:150kDa
Observed MW:150kDa
Reactivity:Human, Mouse, Rat
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Application Key:Western blotting Immunohistochemistry 
Positive Samples:Mouse lung, Mouse large intestine, Mouse spleen, Rat lung, A-549
Cellular Location:

Product Images

Integrin alpha 2 Rabbit Monoclonal Antibody (CAB19068)

Western blot - Integrin alpha 2 Rabbit mAb (CAB19068)

Uniprot Information

UniProt Protein Function:ITGA2: Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix. Belongs to the integrin alpha chain family.
UniProt Protein Details:

Protein type:Cell adhesion; Motility/polarity/chemotaxis; Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 5q11.2

Cellular Component: cell surface; focal adhesion; integrin complex; plasma membrane

Molecular Function:collagen binding; protein binding; protein complex binding

Biological Process: blood coagulation; cell adhesion; cell adhesion mediated by integrin; cell-matrix adhesion; cell-substrate adhesion; extracellular matrix organization and biogenesis; integrin-mediated signaling pathway; mesodermal cell differentiation; organ morphogenesis; substrate-bound cell migration

Disease: Bleeding Disorder, Platelet-type, 9

NCBI Summary:This gene encodes the alpha subunit of a transmembrane receptor for collagens and related proteins. The encoded protein forms a heterodimer with a beta subunit and mediates the adhesion of platelets and other cell types to the extracellular matrix. Loss of the encoded protein is associated with bleeding disorder platelet-type 9. Antibodies against this protein are found in several immune disorders, including neonatal alloimmune thrombocytopenia. This gene is located adjacent to a related alpha subunit gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
UniProt Code:P17301
NCBI GenInfo Identifier:124942
NCBI Gene ID:3673
NCBI Accession:P17301.1
UniProt Secondary Accession:P17301,Q14595,
UniProt Related Accession:P17301
Molecular Weight:129,295 Da
NCBI Full Name:Integrin alpha-2
NCBI Synonym Full Names:integrin subunit alpha 2
NCBI Official Symbol:ITGA2 
NCBI Official Synonym Symbols:BR; GPIa; CD49B; HPA-5; VLA-2; VLAA2 
NCBI Protein Information:integrin alpha-2
UniProt Protein Name:Integrin alpha-2
UniProt Synonym Protein Names:CD49 antigen-like family member B; Collagen receptor; Platelet membrane glycoprotein Ia; GPIa; VLA-2 subunit alpha; CD_antigen: CD49b
Protein Family:Integrin
UniProt Gene Name:ITGA2 
UniProt Entry Name:ITA2_HUMAN
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Additional Information

Product type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
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