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Anti-IL-17A Antibody (CAB0688)

SKU:
CAB0688
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
  • Cell Biology Antibodies 1 Anti-IL-17A Antibody CAB0688
  • Cell Biology Antibodies 1 Anti-IL-17A Antibody CAB0688
€139 - €419
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Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:IL17A Rabbit Polyclonal Antibody
Antibody SKU:CAB0688
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 24-155 of human IL17A (NP_002181.1).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:THP-1
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 24-155 of human IL17A (NP_002181.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:GITI PRNP GCPN SEDK NFPR TVMV NLNI HNRN TNTN PKRS SDYY NRST SPWN LHRN EDPE RYPS VIWE AKCR HLGC INAD GNVD YHMN SVPI QQEI LVLR REPP HCPN SFRL EKIL VSVG CTCV TPIV HHVA
Gene ID:3605
Uniprot:Q16552
Cellular Location:Secreted
Calculated MW:17kDa
Observed MW:17kDa
Synonyms:IL17A, CTLA-8, CTLA8, IL-17, IL-17A, IL17
Background:The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.
UniProt Protein Function:IL17A: Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts. Belongs to the IL-17 family.
UniProt Protein Details:

Protein type:Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 6p12

Cellular Component: extracellular space; external side of plasma membrane

Molecular Function:cytokine activity

Biological Process: cell death; cell-cell signaling; apoptosis; positive regulation of interleukin-23 production; positive regulation of osteoclast differentiation; protein amino acid glycosylation; positive regulation of transcription from RNA polymerase II promoter; immune response; inflammatory response

NCBI Summary:The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Jul 2008]
UniProt Code:Q16552
NCBI GenInfo Identifier:2498481
NCBI Gene ID:3605
NCBI Accession:Q16552.1
UniProt Secondary Accession:Q16552,Q5T2P0,
UniProt Related Accession:Q16552
Molecular Weight:17,504 Da
NCBI Full Name:Interleukin-17A
NCBI Synonym Full Names:interleukin 17A
NCBI Official Symbol:IL17A  
NCBI Official Synonym Symbols:IL17; CTLA8; IL-17; IL-17A  
NCBI Protein Information:interleukin-17A; CTLA-8; cytotoxic T-lymphocyte-associated antigen 8; cytotoxic T-lymphocyte-associated protein 8; interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)
UniProt Protein Name:Interleukin-17A
UniProt Synonym Protein Names:Cytotoxic T-lymphocyte-associated antigen 8; CTLA-8
Protein Family:Interleukin
UniProt Gene Name:IL17A  
UniProt Entry Name:IL17_HUMAN
Anti-IL-17A Antibody (CAB0688)Western blot analysis of extracts of THP-1 cells, using IL17A antibody (CAB0688) at 1:1000 dilution.THP-1 cells were treated by PMA (80 nM) at 37'C for overnight. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 180s.
Anti-IL-17A Antibody (CAB0688)Immunofluorescence analysis of L929 cells using IL17A Rabbit pAb (CAB0688) at dilution of 1:100. Blue: DAPI for nuclear staining.

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