| UniProt Protein Function: | IRF3: interferon regulatory factor 3, a member of the interferon regulatory transcription factor (IRF) family. IRF3 is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes.Protein type: Transcription factor; DNA-bindingChromosomal Location of Human Ortholog: 19q13.3-q13.4Cellular Component: nucleoplasm; cytoplasm; nucleus; cytosolMolecular Function: identical protein binding; protein binding; protein homodimerization activity; DNA binding; transcription cofactor activity; transcription factor activityBiological Process: transcription from RNA polymerase II promoter; negative regulation of interferon-beta biosynthetic process; positive regulation of I-kappaB kinase/NF-kappaB cascade; viral reproduction; apoptosis; MyD88-independent toll-like receptor signaling pathway; cytokine and chemokine mediated signaling pathway; negative regulation of defense response to virus by host; toll-like receptor 3 signaling pathway; negative regulation of transcription from RNA polymerase II promoter; response to exogenous dsRNA; toll-like receptor signaling pathway; lipopolysaccharide-mediated signaling pathway; positive regulation of interferon type I production; positive regulation of interferon-beta production; innate immune response; interferon type I biosynthetic process; response to DNA damage stimulus; defense response to virus; toll-like receptor 4 signaling pathway; negative regulation of interferon type I production; positive regulation of interferon-alpha production; positive regulation of cytokine secretionDisease: Herpes Simplex Encephalitis, Susceptibility To, 7 |
| UniProt Protein Details: | |
| NCBI Summary: | IRF3 encodes interferon regulatory factor 3, a member of the interferon regulatory transcription factor (IRF) family. IRF3 is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. Alternatively spliced transcript variants have been described. [provided by RefSeq] |
| UniProt Code: | Q96GL3 |
| NCBI GenInfo Identifier: | 1107689 |
| NCBI Gene ID: | 3661 |
| NCBI Accession: | |
| UniProt Secondary Accession: | Q96GL3,A8K7L2 |
| UniProt Related Accession: | Q96GL3,Q14653, Q5FBY1, Q5FBY2, Q5FBY4, Q71U93, Q7Z5G6, Q96GL3 |
| Molecular Weight: | 47,219 Da |
| NCBI Full Name: | interferon regulatory factor 3 |
| NCBI Synonym Full Names: | interferon regulatory factor 3 |
| NCBI Official Symbol: | IRF3Â Â |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | interferon regulatory factor 3; IRF-3 |
| UniProt Protein Name: | Interferon regulatory factor 3 |
| UniProt Synonym Protein Names: | |
| Protein Family: | Interferon regulatory factor |
| UniProt Gene Name: | IRF3Â Â |
| UniProt Entry Name: | IRF3_HUMAN |
