Description
JunD (Phospho-Ser255)Transcription Factor Activity Assay
The JUND Phospho-Ser255 Transcription Factor Activity Assay Kit is designed for the accurate measurement of JUND phosphorylation at serine 255 in cell lysates. This kit offers high sensitivity and specificity, allowing for reliable and reproducible results in a variety of research applications.JUND is a transcription factor that plays a critical role in regulating gene expression, particularly in response to stress and inflammatory signals. Phosphorylation of JUND at serine 255 can modulate its transcriptional activity, impacting various cellular processes such as proliferation, apoptosis, and differentiation.
Dysregulation of JUND phosphorylation has been implicated in various diseases, including cancer, inflammation, and metabolic disorders. The JUND Phospho-Ser255 Transcription Factor Activity Assay Kit provides researchers with a valuable tool for studying the role of JUND in disease pathogenesis and identifying potential therapeutic targets.
| Product Name: | JunD (Phospho-Ser255)Transcription Factor Activity Assay |
| Product Code: | TFAB00011 |
| Target: | JunD (Phospho-Ser255) |
| Reactivity: | Human, Mouse, Rat |
| Sample Types: | Nuclear or cell lysates |
The Assay Genie JunD (Phospho-Ser255) transcription factor activity assay allows for the detection and qualitative analysis of JunD (Phospho-Ser255) active transcription factors in eukaryotic nuclear or cell lysates.
Assay Genie ELISA kits are designed to significantly reduce experiment time and ensure sensitivity and flexibility for high-throughput screening.
| Assay Time: | 4.5 hours |
| Detection Method: | Colorimetric 450 nm |
| Size: | 12 x 8-Well Microstrips |
| Storage: | 4°C for 6 months |
| UniProt Protein Function: | JunD: Transcription factor binding AP-1 sites. Binds DNA as a dimer. Interacts with MEN1; this interaction represses transcriptional activation. Belongs to the bZIP family. Jun subfamily. |
| UniProt Protein Details: | Protein type:Transcription factor; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 19p13.2 Cellular Component: chromatin; nuclear chromatin; nucleus; transcription factor complex Molecular Function:enzyme binding; ligand-dependent nuclear receptor binding; protein binding; transcription coactivator activity; transcription factor binding Biological Process: aging; cellular response to hormone stimulus; circadian rhythm; negative regulation of transcription from RNA polymerase II promoter; osteoblast development; positive regulation of cell differentiation; positive regulation of osteoblast differentiation; positive regulation of transcription from RNA polymerase II promoter; regulation of cell cycle; regulation of cell proliferation; regulation of transcription from RNA polymerase II promoter; response to cAMP; response to cytokine stimulus; response to drug; response to light stimulus; response to lipopolysaccharide; response to mechanical stimulus; response to peptide hormone stimulus; response to radiation; transcription from RNA polymerase II promoter |
| NCBI Summary: | The protein encoded by this intronless gene is a member of the JUN family, and a functional component of the AP1 transcription factor complex. This protein has been proposed to protect cells from p53-dependent senescence and apoptosis. Alternative translation initiation site usage results in the production of different isoforms (PMID:12105216). [provided by RefSeq, Nov 2013] |
| UniProt Code: | P17535 |
| NCBI GenInfo Identifier: | 229462969 |
| NCBI Gene ID: | 3727 |
| NCBI Accession: | P17535.3 |
| UniProt Secondary Accession: | P17535,Q53EK9, |
| UniProt Related Accession: | P17535 |
| Molecular Weight: | 35,174 Da |
| NCBI Full Name: | Transcription factor jun-D |
| NCBI Synonym Full Names: | jun D proto-oncogene |
| NCBI Official Symbol: | JUND |
| NCBI Official Synonym Symbols: | AP-1 |
| NCBI Protein Information: | transcription factor jun-D |
| UniProt Protein Name: | Transcription factor jun-D |
| Protein Family: | Transcription factor |
| UniProt Gene Name: | JUND |
| UniProt Entry Name: | JUND_HUMAN |
