[KD Validated] Bcl-XL Polyclonal Antibody
- SKU:
- CAB22241
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
| Product Name: | [KD Validated] Bcl-XL Polyclonal Antibody |
| Product Code: | CAB22241 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:500-1:1000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3. |
| Positive Samples: | A-549, HeLa, L929, C6, PC-12 |
| Cellular Location: | centrosome, cytoplasm, cytosol, endoplasmic reticulum, mitochondrial inner membrane, mitochondrial matrix, mitochondrial outer membrane, mitochondrion, nuclear membrane |
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Alternative splicing results in multiple transcript variants encoding two different isoforms. The longer isoform acts as an apoptotic inhibitor and the shorter isoform acts as an apoptotic activator.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human Bcl-XL (NP_001304848.1). |
| Sequence: | MSQSN RELVV DFLSY KLSQK GYSWS QFSDV EENRT EAPEG TESEM ETPSA INGNP SWHLA DSPAV NGATG HSSSL DAREV IPMAA VKQAL REAGD EFELR YRRAF SDLTS QLHIT PGTAY |
| Synonyms: | BCLX, BCL2L, Bcl-X, PPP1R52, BCL-XL/S |
| Calculated MW: | 26kDa |
| Observed MW: | 30kDa |
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