Anti-ANXA3 Antibody (CAB19861)[KO Validated]

SKU:
CAB19861
€129 - €349

Description

Technical Manual

Anti-ANXA3 Antibody [KO Validated]

Product Name:Anti-ANXA3 Antibody [KO Validated]
Product SKU:CAB19861
Size:20uL, 50 uL
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Background:

This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions in the inhibition of phopholipase A2 and cleavage of inositol 1, 2-cyclic phosphate to form inositol 1-phosphate. This protein may also play a role in anti-coagulation.

Immunogen:Recombinant protein of human ANXA3.
Sequence:

Email for sequence

Gene ID:306
Swiss Prot:P12429
Synonyms:ANXA3; ANX3
Calculated MW:36kDa
Observed MW:34KDa
Reactivity:Human, Rat
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Application Key:Western blotting
Positive Samples:HeLa
Cellular Location:

Product Images

Anti-ANXA3 Antibody [KO Validated] (CAB19861)

Western blot analysis of extracts from normal (control) and ANXA3 knockout (KO) HeLa cells, using ANXA3 antibody (CAB19861) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s.

Uniprot Information

UniProt Protein Function:ANXA3: a calcium/phospholipid-binding protein and inhibitor of phospholipase A2, Possesses anti-coagulant properties. Cleaves the cyclic bond of inositol 1,2-cyclic phosphate to form inositol 1-phosphate. Annexins are a family of structurally related proteins whose common property is calcium-dependent binding to phospholipids. There are at least ten different annexins in mammalian species. Annexins do not contain signal peptides, yet some annexins (A1, A2 and A5) appear to be secreted in a physiologically regulated fashion.
UniProt Protein Details:

Protein type:Calcium-binding

Chromosomal Location of Human Ortholog: 4q21.21

Cellular Component: cytoplasm; membrane; phagocytic vesicle membrane; plasma membrane; specific granule

Molecular Function:calcium-dependent phospholipid binding; calcium-dependent protein binding

Biological Process: defense response to bacterium; neutrophil degranulation; phagocytosis; positive regulation of angiogenesis; positive regulation of transcription factor activity

NCBI Summary:This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions in the inhibition of phopholipase A2 and cleavage of inositol 1,2-cyclic phosphate to form inositol 1-phosphate. This protein may also play a role in anti-coagulation. [provided by RefSeq, Jul 2008]
UniProt Code:P12429
NCBI GenInfo Identifier:113954
NCBI Gene ID:306
NCBI Accession:P12429.3
UniProt Secondary Accession:P12429,Q6LET2, B2R9W6,
UniProt Related Accession:P12429
Molecular Weight:36,375 Da
NCBI Full Name:Annexin A3
NCBI Synonym Full Names:annexin A3
NCBI Official Symbol:ANXA3
NCBI Official Synonym Symbols:ANX3
NCBI Protein Information:annexin A3
UniProt Protein Name:Annexin A3
UniProt Synonym Protein Names:35-alpha calcimedin; Annexin III; Annexin-3; Inositol 1,2-cyclic phosphate 2-phosphohydrolase; Lipocortin III; Placental anticoagulant protein III; PAP-III
Protein Family:Annexin
UniProt Gene Name:ANXA3
UniProt Entry Name:ANXA3_HUMAN
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Additional Information

Product type:
Antibody
Reactivity:
Human
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Signal Transduction
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