Anti-ATOX1 Antibody (CAB19925)

Antibody Name:	Anti-ATOX1 Antibody [KO Validated]
Antibody SKU:	CAB19925
Antibody Size:	20uL, 50uL, 100uL
Application:	WB IF
Reactivity:	Human
Host Species:	Rabbit
Immunogen:	Recombinant protein of human ATOX1.

Application:	WB IF
Recommended Dilution:	WB 1:500 - 1:2000 IF 1:50 - 1:100
Reactivity:	Human
Positive Samples:	293T

Immunogen:	Recombinant protein of human ATOX1.
Purification Method:	Affinity purification
Storage Buffer:	Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	Email for sequence
Gene ID:	475
Uniprot:	O00244
Cellular Location:
Calculated MW:	7kDa
Observed MW:	7KDa

Anti-ATOX1 Antibody [KO Validated] (CAB19925)

Western blot analysis of extracts from normal (control) and ATOX1 knockout (KO) 293T cells, using ATOX1 antibody (CAB19925) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s.

Synonyms:

ATOX1, ATX1, HAH1

Background:

This gene encodes a copper chaperone that plays a role in copper homeostasis by binding and transporting cytosolic copper to ATPase proteins in the trans-Golgi network for later incorporation to the ceruloplasmin. This protein also functions as an antioxidant against superoxide and hydrogen peroxide, and therefore, may play a significant role in cancer carcinogenesis. Because of its cytogenetic location, this gene represents a candidate gene for 5q-syndrome.

UniProt Protein Function:	ATOX1: Could bind and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense. Belongs to the ATX1 family.
UniProt Protein Details:	Protein type:Carrier Chromosomal Location of Human Ortholog: 5q32 Cellular Component: cytosol Molecular Function:metallochaperone activity; copper ion transmembrane transporter activity; copper ion binding; copper chaperone activity; copper-dependent protein binding Biological Process: response to reactive oxygen species; cellular copper ion homeostasis; response to oxidative stress; copper ion transport; intracellular copper ion transport
NCBI Summary:	This gene encodes a copper chaperone that plays a role in copper homeostasis by binding and transporting cytosolic copper to ATPase proteins in the trans-Golgi network for later incorporation to the ceruloplasmin. This protein also functions as an antioxidant against superoxide and hydrogen peroxide, and therefore, may play a significant role in cancer carcinogenesis. Because of its cytogenetic location, this gene represents a candidate gene for 5q-syndrome. [provided by RefSeq, Jul 2008]
UniProt Code:	O00244
NCBI GenInfo Identifier:	7531045
NCBI Gene ID:	475
NCBI Accession:	O00244.1
UniProt Secondary Accession:	O00244,Q2M1R6, Q56AP3, A8KAJ8, D3DQI2,
UniProt Related Accession:	O00244
Molecular Weight:	68
NCBI Full Name:	Copper transport protein ATOX1
NCBI Synonym Full Names:	antioxidant 1 copper chaperone
NCBI Official Symbol:	ATOX1
NCBI Official Synonym Symbols:	ATX1; HAH1
NCBI Protein Information:	copper transport protein ATOX1; metal transport protein ATX1; ATX1 antioxidant protein 1 homolog
UniProt Protein Name:	Copper transport protein ATOX1
UniProt Synonym Protein Names:	Metal transport protein ATX1
Protein Family:	Copper transport protein
UniProt Gene Name:	ATOX1
UniProt Entry Name:	ATOX1_HUMAN

Antibodies

Anti-ATOX1 Antibody (CAB6874)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)