[KO Validated] Bax Rabbit Monoclonal Antibody (CAB19684)
- SKU:
- CAB19684
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Death
Description
Product Name: | [KO Validated] Bax Rabbit Monoclonal Antibody |
SKU: | CAB19684 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Bax (Q07812). |
Sequence: | MDGS GEQP RGGG PTSS EQIM KTGA LLLQ GFIQ DRAG RMGG EAPE LALD PVPQ DAST KKLS ECLK RIGD ELDS NMEL QRMI AAVD TDSP REVF FRVA ADMF |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 |
Synonyms: | BCL2L4; Bax |
Positive Sample: | 293T,Raji,HeLa,Mouse lung,RAW 264.7,Rat testis,Rat lung,Raji,RAW 264.7,293T |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Cytoplasm, Mitochondrion membrane, Single-pass membrane protein. |
Calculated MW: | 21kDa |
Observed MW: | 21kDa/ |
The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. The association and the ratio of BAX to BCL2 also determines survival or death of a cell following an apoptotic stimulus. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene.
Purification Method: | Affinity purification |
Gene ID: | 581 |
Clone Number: | ARC0164 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3. |