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[KO Validated] MTA2 Rabbit Monoclonal Antibody (CAB4624)

SKU:
CAB4624
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
WB
IHC
IF
IP
ChIP
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
MTA1L1
PID
Research Area:
Cell Biology
  • KO Validated Antibodies 2 Anti-MTA2 KO Validated Antibody CAB4624
  • KO Validated Antibodies 2 Anti-MTA2 KO Validated Antibody CAB4624
  • KO Validated Antibodies 2 Anti-MTA2 KO Validated Antibody CAB4624
  • KO Validated Antibodies 2 Anti-MTA2 KO Validated Antibody CAB4624
€139 - €419
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Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:[KO Validated] MTA2 Rabbit Monoclonal Antibody
SKU:CAB4624
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 569-668 of human MTA2 (O94776).
Sequence:GVPF SANG RPLA SGIR SSSQ PAAK RQKL NPAD APNP VVFV ATKD TRAL RKAL THLE MRRA ARRP NLPL KVKP TLIA VRPP VPLP APSH PAST NEPI VLED
Tested Applications:WB IHC-P IF/ICC ChIP ELISA
Recommended Dilution:WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 ChIP,5μg antibody for 10μg-15μg of Chromatin
Synonyms:PID; MTA1L1; A2
Positive Sample:HeLa,293T
Conjugate:Unconjugated
Cellular Localization:Nucleus.
Calculated MW:75kDa
Observed MW:75kDa

This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small gene family that encode different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacetylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis.

Purification Method:Affinity purification
Gene ID:9219
Clone Number:ARC1056
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates using MTA2 Rabbit mAb (CAB4624) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3min.

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