[KO Validated] CASP1 Rabbit Polyclonal Antibody (CAB18646)
- SKU:
- CAB18646
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Death
Description
Product Name: | [KO Validated] CASP1 Rabbit Polyclonal Antibody |
SKU: | CAB18646 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 198-297 of human CASP1 (NP_150634.1). |
Sequence: | YSVD VKKN LTAS DMTT ELEA FAHR PEHK TSDS TFLV FMSH GIRE GICG KKHS EQVP DILQ LNAI FNML NTKN CPSL KDKP KVII IQAC RGDS PGVV WFKD |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200 |
Synonyms: | ICE; P45; IL1BC; CASP1 |
Positive Sample: | HepG2,Mouse testis |
Cellular Localization: | Cytoplasm. |
Calculated MW: | 45kDa |
Observed MW: | 48kDa |
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms.
Purification Method: | Affinity purification |
Gene ID: | 834 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |