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[KO Validated] TMED10 Rabbit Polyclonal Antibody (CAB18090)

SKU:
CAB18090
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
€139 - €419
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:[KO Validated] TMED10 Rabbit Polyclonal Antibody
SKU:CAB18090
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 35-190 of human TMED10 (NP_006818.3).
Sequence:HLPI NSRK CLRE EIHK DLLV TGAY EISD QSGG AGGL RSHL KITD SAGH ILYS KEDA TKGK FAFT TEDY DMFE VCFE SKGT GRIP DQLV ILDM KHGV EAKN YEEI AKVE KLKP LEVE LRRL EDLS ESIV NDFA YMKK REEE MRDT NEST NTRV LYFS
Tested Applications:WB IF/ICC ELISA
Recommended Dilution:WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200
Synonyms:p23; TMP21; p24d1; S31I125; Tmp-21-I; S31III125; P24(DELTA); 10
Positive Sample:293T
Conjugate:Unconjugated
Cellular Localization:Cell membrane, Cytoplasmic vesicle, Endoplasmic reticulum membrane, Endoplasmic reticulum-Golgi intermediate compartment membrane, Golgi apparatus, Melanosome, Single-pass type I membrane protein, cis-Golgi network membrane, secretory vesicle membrane, trans-Golgi
Calculated MW:25kDa
Observed MW:21kDa

This gene is a member of the EMP24/GP25L/p24 family and encodes a protein with a GOLD domain. This type I membrane protein is localized to the plasma membrane and golgi cisternae and is involved in vesicular protein trafficking. The protein is also a member of a heteromeric secretase complex and regulates the complex's gamma-secretase activity without affecting its epsilon-secretase activity. Mutations in this gene have been associated with early-onset familial Alzheimer's disease. This gene has a pseudogene on chromosome 8.

Purification Method:Affinity purification
Gene ID:10972
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Product ImageWestern blot analysis of lysates from wild type (WT) and TMED10 knockout (KO) 293T cells, using [KO Validated] TMED10 Rabbit pAb (CAB18090) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.

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