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Anti-YAP1 Antibody (CAB1002)[KO Validated]

SKU:
CAB1002
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling
  • KO Validated Antibodies 1 Anti-YAP1 Antibody CAB1002KO Validated
  • KO Validated Antibodies 1 Anti-YAP1 Antibody CAB1002KO Validated
  • KO Validated Antibodies 1 Anti-YAP1 Antibody CAB1002KO Validated
  • KO Validated Antibodies 1 Anti-YAP1 Antibody CAB1002KO Validated
  • KO Validated Antibodies 1 Anti-YAP1 Antibody CAB1002KO Validated
€129 - €359
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Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-YAP1 Antibody [KO Validated]
Antibody SKU:CAB1002
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC IF IP
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 155-504 of human YAP1 (NP_001123617.1).
Application:WB IHC IF IP
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 IP 1:20 - 1:50
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa, LO2, BT-474, A549
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 155-504 of human YAP1 (NP_001123617.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:PTAQ HLRQ SSFE IPDD VPLP AGWE MAKT SSGQ RYFL NHID QTTT WQDP RKAM LSQM NVTA PTSP PVQQ NMMN SASG PLPD GWEQ AMTQ DGEI YYIN HKNK TTSW LDPR LDPR FAMN QRIS QSAP VKQP PPLA PQSP QGGV MGGS NSNQ QQQM RLQQ LQME KERL RLKQ QELL RQAM RNIN PSTA NSPK CQEL ALRS QLPT LEQD GGTQ NPVS SPGM SQEL RTMT TNSS DPFL NSGT YHSR DEST DSGL SMSS YSVP RTPD DFLN SVDE MDTG DTIN QSTL PSQQ NRFP DYLE AIPG TNVD LGTL EGDG MNIE GEEL MPSL QEAL SSDI LNDM ESVL AATK LDKE SFLT WL
Gene ID:10413
Uniprot:P46937
Cellular Location:Cytoplasm, Nucleus
Calculated MW:36kDa/48kDa/49kDa/50kDa/52kDa/53kDa/54kDa
Observed MW:72kDa
Synonyms:COB1, YAP, YAP2, YAP65, YKI, YAP1
Background:This gene encodes a downstream nuclear effector of the Hippo signaling pathway which is involved in development, growth, repair, and homeostasis. This gene is known to play a role in the development and progression of multiple cancers as a transcriptional regulator of this signaling pathway and may function as a potential target for cancer treatment. Alternative splicing results in multiple transcript variants encoding different isoforms.
UniProt Code:P46937
NCBI GenInfo Identifier:294862479
NCBI Gene ID:10413
NCBI Accession:P46937.2
UniProt Secondary Accession:P46937,Q7Z574, B4DTY1, B7ZA01, E3WEB5, E3WEB6, E9PRV2 F5H202, K0KQ18, K0KYZ8, K0L195, K0L1G3,
UniProt Related Accession:P46937
Molecular Weight:504
NCBI Full Name:Transcriptional coactivator YAP1
NCBI Synonym Full Names:Yes-associated protein 1
NCBI Official Symbol:YAP1  
NCBI Official Synonym Symbols:YAP; YKI; COB1; YAP2; YAP65  
NCBI Protein Information:transcriptional coactivator YAP1; yorkie homolog; protein yorkie homolog; yes-associated protein 2; 65 kDa Yes-associated protein; yes-associated protein YAP65 homolog
UniProt Protein Name:Transcriptional coactivator YAP1
UniProt Synonym Protein Names:Protein yorkie homolog; Yes-associated protein YAP65 homolog
Protein Family:Transcriptional coactivator
UniProt Gene Name:YAP1  
UniProt Entry Name:YAP1_HUMAN
Anti-YAP1 Antibody [KO Validated] (CAB1002)Western blot analysis of extracts of various cell lines, using YAP1 antibody (CAB1002) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.
Anti-YAP1 Antibody [KO Validated] (CAB1002)Western blot analysis of extracts from normal (control) and [KO Validated] YAP1 Rabbit pAb knockout (KO) HeLa cells, using [KO Validated] YAP1 Rabbit pAb antibody (CAB1002) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s.
Anti-YAP1 Antibody [KO Validated] (CAB1002)Immunohistochemistry of paraffin-embedded human placenta using YAP1 antibody (CAB1002) at dilution of 1:100 (40x lens).
Anti-YAP1 Antibody [KO Validated] (CAB1002)Immunohistochemistry of paraffin-embedded rat kidney using YAP1 antibody (CAB1002) at dilution of 1:100 (40x lens).
Anti-YAP1 Antibody [KO Validated] (CAB1002)Immunohistochemistry of paraffin-embedded mouse heart using YAP1 antibody (CAB1002) at dilution of 1:100 (40x lens).

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