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Anti-LETM1 Antibody (CAB15685)

SKU:
CAB15685
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction
€139 - €419
Frequently bought together:

Description

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Antibody Name:Anti-LETM1 Antibody
Antibody SKU:CAB15685
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-140 of human LETM1 (NP_036450.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:A-431, HeLa, Mouse heart, Mouse liver, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-140 of human LETM1 (NP_036450.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MASI LLRS CRGR APAR LPPP PRYT VPRG SPGD PAHL SCAS TLGL RNCL NVPF GCCT PIHP VYTS SRGD HLGC WALR PECL RIVS RAPW TSTS VGFV AVGP QCLP VRGW HSSR PVRD DSVV EKSL KSLK DKNK KLEE GGPV
Gene ID:3954
Uniprot:O95202
Cellular Location:Mitochondrion inner membrane, Single-pass membrane protein
Calculated MW:29kDa/33kDa/83kDa
Observed MW:83kDa
Synonyms:LETM1
Background:This gene encodes a protein that is localized to the inner mitochondrial membrane. The protein functions to maintain the mitochondrial tubular shapes and is required for normal mitochondrial morphology and cellular viability. Mutations in this gene cause Wolf-Hirschhorn syndrome, a complex malformation syndrome caused by the deletion of parts of the distal short arm of chromosome 4. Related pseudogenes have been identified on chromosomes 8, 15 and 19.
UniProt Protein Function:Function: Crucial for the maintenance of mitochondrial tubular networks and for the assembly of the supercomplexes of the respiratory chain. Required for the maintenance of the tubular shape and cristae organization. Ref.7
UniProt Protein Details:

Subunit structure: Can form 2 complexes: a major (300 kDa) and a minor complex (500-600 kDa). Interacts with BCS1L. Ref.7

Subcellular location: Mitochondrion inner membrane; Single-pass membrane protein Ref.5 Ref.6 Ref.7.

Sequence similarities: Contains 1 EF-hand domain.Contains 1 LETM1 domain.

Sequence caution: The sequence CAB63769.2 differs from that shown. Reason: Erroneous translation. Incomplete prediction of CDS at the C-terminus.

NCBI Summary:This gene encodes a protein that is localized to the inner mitochondrial membrane. The protein functions to maintain the mitochondrial tubular shapes and is required for normal mitochondrial morphology and cellular viability. Mutations in this gene cause Wolf-Hirschhorn syndrome, a complex malformation syndrome caused by the deletion of parts of the distal short arm of chromosome 4. Related pseudogenes have been identified on chromosomes 8, 15 and 19. [provided by RefSeq, Oct 2009]
UniProt Code:O95202
NCBI GenInfo Identifier:62510844
NCBI Gene ID:3954
NCBI Accession:O95202.1
UniProt Secondary Accession:O95202,Q9UF65, B4DED2,
UniProt Related Accession:O95202
Molecular Weight:83,354 Da
NCBI Full Name:LETM1 and EF-hand domain-containing protein 1, mitochondrial
NCBI Synonym Full Names:leucine zipper-EF-hand containing transmembrane protein 1
NCBI Official Symbol:LETM1  
NCBI Protein Information:LETM1 and EF-hand domain-containing protein 1, mitochondrial; Mdm38 homolog; leucine zipper-EF-hand-containing transmembrane protein 1
UniProt Protein Name:LETM1 and EF-hand domain-containing protein 1, mitochondrial
UniProt Synonym Protein Names:Leucine zipper-EF-hand-containing transmembrane protein 1
Protein Family:LETM1 and EF-hand domain-containing protein
UniProt Gene Name:LETM1  
UniProt Entry Name:LETM1_HUMAN
Anti-LETM1 Antibody (CAB15685)Western blot analysis of extracts of various cell lines, using LETM1 antibody (CAB15685) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.

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