The LOXL4 Polyclonal Antibody (PAC052658) is a valuable tool for researchers studying the LOXL4 protein, an enzyme implicated in extracellular matrix remodeling and tissue development. This antibody, raised in rabbits, exhibits high reactivity with human samples and is verified for use in Western blot applications. By binding specifically to the LOXL4 protein, this antibody enables precise detection and analysis in a variety of cell types, making it ideal for investigations in molecular biology and disease pathology.
LOXL4, a member of the lysyl oxidase-like family, is known for its crucial role in collagen cross-linking and elastin fiber formation, contributing to the structural integrity of tissues. Studies have shown dysregulation of LOXL4 in diseases such as fibrosis, cancer, and cardiovascular disorders, highlighting its potential as a therapeutic target. Understanding the function of LOXL4 is essential for developing interventions that target tissue remodeling processes and mitigate disease progression.
Antibody Name:
Loxl4 Antibody (PACO52658)
Antibody SKU:
PACO52658
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:5000
Species Reactivity:
Mouse, Rat
Immunogen:
Recombinant Mouse Lysyl oxidase homolog 4 protein (26-757AA)
Western Blot. Positive WB detected in: Rat brain tissue. All lanes: Loxl4 antibody at 4µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 85 kDa. Observed band size: 85 kDa.
Background:
May modulate the formation of a collagenous extracellular matrix.
Synonyms:
Lysyl oxidase homolog 4 (EC 1.4.3) (Lysyl oxidase-like protein 4) (Lysyl oxidase-related protein C), Loxl4, Loxc
UniProt Protein Function:
LOXL4: May modulate the formation of a collagenous extracellular matrix. Belongs to the lysyl oxidase family.Protein type: Secreted, signal peptide; EC 1.4.3.-; Oxidoreductase; SecretedCellular Component: extracellular region; membrane; receptor complexMolecular Function: aspartate oxidase activity; copper ion binding; metal ion binding; oxidoreductase activity; oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor; protein-lysine 6-oxidase activity; scavenger receptor activity
