LRP1 Antibody is a rabbit polyclonal antibody directed against LRP1, offered by Assay Genie for research applications. Reported applications include WB and IHC. Reported reactivity: Human, Mouse and Rat. Purified by Peptide Affinity.
LRP1 (Low-Density Lipoprotein Receptor-Related Protein 1) is a multifunctional endocytic receptor involved in lipid metabolism, protease clearance, and cell signaling. In the brain, LRP1 regulates amyloid-beta clearance, synaptic plasticity, and blood-brain barrier integrity. Dysregulation of LRP1 is associated with Alzheimer’s disease, where impaired Aβ clearance contributes to plaque accumulation and neurotoxicity. LRP1 also modulates neuroinflammatory responses and interacts with key signaling pathways, including Wnt and TGF-β. Its broad functional repertoire and role in maintaining neural homeostasis make LRP1 a critical target in neurodegenerative disease research and therapeutic development. This antibody is also available conjugated to ATTO 390, ATTO 488, ATTO 594, APC, Biotin, FITC, HRP, PerCP and RPE. Supplied in 100 µg. For research use only; not for diagnostic or therapeutic procedures.
Product Name:
LRP1 Antibody
Product SKU:
STPA00084
Size:
100 µg
Target:
LRP1
Host Species:
Rabbit
Antibody Type:
Polyclonal
Research Areas:
Neuroscience, Neurodegeneration, Alzheimer's Disease, Cardiovascular System, Blood, Cancer, Apoptosis, Cancer Metabolism, Cardiovascular System, Atherosclerosis, Cancer, Cell Death
Buffer:
PBS pH 7.4, 50% glycerol, 0.09% sodium azide
Storage & Shipping:
Store at -20°C. Shipped on Blue Ice or 4°C. Conjugated variants should be stored according to the product label.
Format:
Liquid
Applications:
WB, IHC
Purification:
Peptide Affinity Purified
Concentration:
1 mg/ml
Reactivity:
Human, Mouse, Rat
Recommended Dilution:
WB (1:1000); IHC (1:50); optimal dilutions for assays should be determined by the user.
Specificity:
Detects 80 kDa. Band at 80 kDa is a membrane spanning subunit.
Guarantee:
12 months from date of dispatch
Immunogen:
Synthetic peptide from the N-terminal of Human Low-density lipoprotein receptor-related protein 1 (aa. 160-260)
Immunogen Species:
Human
Accession Number:
NP_002323.2
Gene ID:
4035
Swiss-Prot:
Q07954
Cellular Localization:
Cell Membrane | Single-Pass Type I Membrane Protein | Membrane | Coated Pit
Tissue Specificity:
Most abundant in liver, brain and lung.
Alternative Names:
LRP1, LRP-1, LRP-85, LRP-515, Alpha-2-macroglobulin receptor, A2MR, Apolipoprotein E receptor, Prolow-density lipoprotein receptor-related protein 1, CD91, LRPICD, APOER, APR
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