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Anti-LSP1 Antibody (CAB5617)

SKU:
CAB5617
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
  • Cell Biology Antibodies 9 Anti-LSP1 Antibody CAB5617
  • Cell Biology Antibodies 9 Anti-LSP1 Antibody CAB5617
  • Cell Biology Antibodies 9 Anti-LSP1 Antibody CAB5617
€139 - €419
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Description

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Antibody Name:Anti-LSP1 Antibody
Antibody SKU:CAB5617
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-339 of human LSP1 (NP_002330.1).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse
Positive Samples:Mouse lung, Mouse spleen
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-339 of human LSP1 (NP_002330.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MAEA SSDP GAEE REEL LGPT AQWS VEDE EEAV HEQC QHER DRQL QAQD EEGG GHVP ERPK QEML LSLK PSEA PELD EDEG FGDW SQRP EQRQ QHEG AQGA LDSG EPPQ CRSP EGEQ EDRP GLHA YEKE DSDE VHLE ELSL SKEG PGPE DTVQ DNLG AAGA EEEQ EEHQ KCQQ PRTP SPLV LEGT IEQS SPPL SPTT KLID RTES LNRS IEKS NSVK KSQP DLPI SKID QWLE QYTQ AIET AGRT PKLA RQAS IELP SMAV ASTK SRWE TGEV QAQS AAKT PSCK DIVA GDMS KKSL WEQK GGSK TSST IKST PSGK RYKF VATG HGKY EKVL VEGG PAP
Gene ID:4046
Uniprot:P33241
Cellular Location:Cell membrane, Cytoplasmic side, Peripheral membrane protein
Calculated MW:30kDa/37kDa/50kDa
Observed MW:55kDa
Synonyms:LSP1, WP34, pp52
Background:This gene encodes an intracellular F-actin binding protein. The protein is expressed in lymphocytes, neutrophils, macrophages, and endothelium and may regulate neutrophil motility, adhesion to fibrinogen matrix proteins, and transendothelial migration. Alternative splicing results in multiple transcript variants encoding different isoforms.
UniProt Protein Function:LSP1: May play a role in mediating neutrophil activation and chemotaxis. Binds actin. Activated T-lymphocytes.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis; Actin-binding

Chromosomal Location of Human Ortholog: 11p15.5

Cellular Component: membrane; plasma membrane; actin cytoskeleton

Molecular Function:signal transducer activity; actin binding

Biological Process: cellular defense response; cell motility; signal transduction; chemotaxis

NCBI Summary:This gene encodes an intracellular F-actin binding protein. The protein is expressed in lymphocytes, neutrophils, macrophages, and endothelium and may regulate neutrophil motility, adhesion to fibrinogen matrix proteins, and transendothelial migration. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
UniProt Code:P33241
NCBI GenInfo Identifier:462553
NCBI Gene ID:4046
NCBI Accession:P33241.1
UniProt Secondary Accession:P33241,Q16096, Q53H48, Q6FHM3, Q9BUY8, B3KPP1, B3KRR6 E9PBV6, E9PFP3,
UniProt Related Accession:P33241
Molecular Weight:339
NCBI Full Name:Lymphocyte-specific protein 1
NCBI Synonym Full Names:lymphocyte-specific protein 1
NCBI Official Symbol:LSP1  
NCBI Official Synonym Symbols:WP34; pp52  
NCBI Protein Information:lymphocyte-specific protein 1; 52 kDa phosphoprotein; 47 kDa actin binding protein; 47 kDa actin-binding protein; leukocyte-specific protein 1; lymphocyte-specific antigen WP34; leufactin (leukocyte F-actin binding protein); F-actin binding and cytoskeleton associated protein
UniProt Protein Name:Lymphocyte-specific protein 1
UniProt Synonym Protein Names:47 kDa actin-binding protein; 52 kDa phosphoprotein; pp52; Lymphocyte-specific antigen WP34
Protein Family:Lymphocyte-specific protein
UniProt Gene Name:LSP1  
UniProt Entry Name:LSP1_HUMAN
Anti-LSP1 Antibody (CAB5617)Western blot analysis of extracts of various cell lines, using LSP1 antibody (CAB5617) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 30s.
Anti-LSP1 Antibody (CAB5617)Immunohistochemistry of paraffin-embedded human gastric cancer using LSP1 Antibody (CAB5617) at dilution of 1:100 (40x lens).
Anti-LSP1 Antibody (CAB5617)Immunohistochemistry of paraffin-embedded human adenomyosis using LSP1 Antibody (CAB5617) at dilution of 1:100 (40x lens).

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