Anti-LTA4H Antibody (CAB2502)
- SKU:
- CAB2502
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Metabolism
Frequently bought together:
Description
| Antibody Name: | Anti-LTA4H Antibody |
| Antibody SKU: | CAB2502 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 312-611 of human LTA4H (NP_000886.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: | 293T, HepG2, PC-3, SW620, BT-474, Ramos, Mouse spleen, Mouse brain, Mouse bone marrow |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 312-611 of human LTA4H (NP_000886.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | WDHF WLNE GHTV YLER HICG RLFG EKFR HFNA LGGW GELQ NSVK TFGE THPF TKLV VDLT DIDP DVAY SSVP YEKG FALL FYLE QLLG GPEI FLGF LKAY VEKF SYKS ITTD DWKD FLYS YFKD KVDV LNQV DWNA WLYS PGLP PIKP NYDM TLTN ACIA LSQR WITA KEDD LNSF NATD LKDL SSHQ LNEF LAQT LQRA PLPL GHIK RMQE VYNF NAIN NSEI RFRW LRLC IQSK WEDA IPLA LKMA TEQG RMKF TRPL FKDL AAFD KSHD QAVR TYQE HKAS MHPV TAML VGKD LKVD |
| Gene ID: | 4048 |
| Uniprot: | P09960 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 57kDa/59kDa/66kDa/69kDa |
| Observed MW: | 69kDa |
| Synonyms: | LTA4H |
| Background: | The protein encoded by this gene is an enzyme that contains both hydrolase and aminopeptidase activities. The hydrolase activity is used in the final step of the biosynthesis of leukotriene B4, a proinflammatory mediator. The aminopeptidase activity has been shown to degrade proline-glycine-proline (PGP), a neutrophil chemoattractant and biomarker for chronic obstructive pulmonary disease (COPD). Several transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | LTA4H: Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity. Belongs to the peptidase M1 family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 3.3.2.6; Hydrolase; Lipid Metabolism - arachidonic acid Chromosomal Location of Human Ortholog: 12q22 Cellular Component: nucleoplasm; cytoplasm; cytosol Molecular Function:peptidase activity; leukotriene-A4 hydrolase activity; metallopeptidase activity; zinc ion binding; epoxide hydrolase activity; aminopeptidase activity Biological Process: leukotriene biosynthetic process; peptide catabolic process; arachidonic acid metabolic process; leukotriene metabolic process; proteolysis; inflammatory response |
| NCBI Summary: | The protein encoded by this gene is an enzyme that contains both hydrolase and aminopeptidase activities. The hydrolase activity is used in the final step of the biosynthesis of leukotriene B4, a proinflammatory mediator. The aminopeptidase activity has been shown to degrade proline-glycine-proline (PGP), a neutrophil chemoattractant and biomarker for chronic obstructive pulmonary disease (COPD). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015] |
| UniProt Code: | P09960 |
| NCBI GenInfo Identifier: | 126353 |
| NCBI Gene ID: | 4048 |
| NCBI Accession: | P09960.2 |
| UniProt Related Accession: | P09960 |
| Molecular Weight: | ~ 69kDa |
| NCBI Full Name: | Leukotriene A-4 hydrolase |
| NCBI Synonym Full Names: | leukotriene A4 hydrolase |
| NCBI Official Symbol: | LTA4HÂ Â |
| NCBI Protein Information: | leukotriene A-4 hydrolase |
| UniProt Protein Name: | Leukotriene A-4 hydrolase |
| UniProt Synonym Protein Names: | Leukotriene A(4) hydrolase |
| Protein Family: | Leukotriene A-4 hydrolase |
| UniProt Gene Name: | LTA4HÂ Â |
| UniProt Entry Name: | LKHA4_HUMAN |
 | Western blot analysis of extracts of various cell lines, using LTA4H antibody (CAB2502) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
 | Immunofluorescence analysis of HeLa cells using LTA4H antibody (CAB2502). Blue: DAPI for nuclear staining. |
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