The MEK6 Antibody (CAB2575) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced in rabbits, exhibits high specificity and sensitivity for detecting MAP2K6 in human samples, making it ideal for use in Western blot applications.MAP2K6, also known as dual specificity mitogen-activated protein kinase kinase 6, plays a crucial role in activating MAPK pathways that control various cellular processes, including proliferation, differentiation, and apoptosis. Dysregulation of MAP2K6 has been implicated in several diseases, such as cancer, cardiovascular disorders, and neurological conditions, highlighting its relevance as a therapeutic target.
This antibody is validated for use in WB, IF/ICC, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.
Product Name:
MEK6 Antibody
SKU:
CAB2575
Size:
20μL, 100μL
Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Immunogen:
Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:
MEK6, MKK6, MAPKK6, PRKMK6, SAPKK3, SAPKK-3
Positive Sample:
HeLa
Cellular Localization:
Cytoplasm, Nucleus, Cytoskeleton.
Calculated MW:
37kDa
Observed MW:
37kDa
This gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis.
Purification Method
Affinity purification
Gene ID
5608
RRID
AB_2764461
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Western blot analysis of various lysates using MEK6 Rabbit pAb (CAB2575) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 10s.
Western blot analysis of lysates from HeLa cells, using MEK6 Rabbit pAb (CAB2575) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST.
