UniProt Protein Function: | MARS2: Belongs to the class-I aminoacyl-tRNA synthetase family.Protein type: Other Amino Acids Metabolism - selenoamino acid; EC 6.1.1.10; Mitochondrial; LigaseChromosomal Location of Human Ortholog: 2q33.1Cellular Component: cytosol; mitochondrial matrixMolecular Function: methionine-tRNA ligase activityBiological Process: methionyl-tRNA aminoacylation; tRNA aminoacylation for protein translationDisease: Combined Oxidative Phosphorylation Deficiency 25; Spastic Ataxia 3, Autosomal Recessive |
UniProt Protein Details: | |
NCBI Summary: | This gene produces a mitochondrial methionyl-tRNA synthetase protein that is encoded by the nuclear genome and imported to the mitochondrion. This protein likely functions as a monomer and is predicted to localize to the mitochondrial matrix. Mutations in this gene are associated with the autosomal recessive neurodegenerative disease spastic ataxia-3 (SPAX3). [provided by RefSeq, Apr 2014] |
UniProt Code: | Q96GW9 |
NCBI GenInfo Identifier: | 85541638 |
NCBI Gene ID: | 92935 |
NCBI Accession: | Q96GW9.2 |
UniProt Secondary Accession: | Q96GW9,Q76E79, Q8IW62, Q8N7N4, A0AVC3 |
UniProt Related Accession: | Q96GW9 |
Molecular Weight: | 66,591 Da |
NCBI Full Name: | Methionine--tRNA ligase, mitochondrial |
NCBI Synonym Full Names: | methionyl-tRNA synthetase 2, mitochondrial |
NCBI Official Symbol: | MARS2Â Â |
NCBI Official Synonym Symbols: | MetRS; COXPD25; mtMetRSÂ Â |
NCBI Protein Information: | methionine--tRNA ligase, mitochondrial |
UniProt Protein Name: | Methionine--tRNA ligase, mitochondrial |
UniProt Synonym Protein Names: | Methionyl-tRNA synthetase 2; Mitochondrial methionyl-tRNA synthetase; MtMetRS |
Protein Family: | |
UniProt Gene Name: | MARS2Â Â |
UniProt Entry Name: | SYMM_HUMAN |