MK-4721 (Research-Grade) is a research-grade biosimilar monoclonal antibody. Format: scFv-hFc (human host). Reactivity: Human. Supplied as a liquid in 0.01M PBS pH 7.4. Applications: ELISA, flow cytometry, functional assays and in vivo research. Endotoxin: < 10 EU/mg. Purity: >95% purity as determined by SDS-PAGE. For research use only.
Prostate stem cell antigen (PSCA) is a ~11 kDa protein. May be involved in the regulation of cell proliferation. Has a cell-proliferation inhibition activity in vitro.
Product Name:
MK-4721 (Research-Grade)
SKU:
GXBS01480
Size:
100 µg, 1 mg
Antibody Type:
Monoclonal Antibody
Target:
Prostate stem cell antigen
Isotype:
scFv-hFc
Host Species:
Human
Reactivity:
Human
Applications:
ELISA, FACS, Functional assay, Research in vivo
Expression Host:
Mammalian cells
Synonyms:
ProscamabA11, MK-4721
Biological Activity:
AGS-1C4D4 displays potent ADCC activity against PSCA-expressing HPAC and Panc0203 pancreatic cell lines, with activity greatly reduced by deglycosylation, and is more potent than the hybridoma-derived AGS-PSCA antibody in this assay [1]. AGS-1C4D4 exhibits CDC activity against PSCA-expressing recombinant B300.19 cells, with activity greatly reduced by deglycosylation, and is equally effective as the hybridoma-derived AGS-PSCA antibody in this assay [1]. AGS-1C4D4 binds to PSCA with a K d of 0.2 nM, displaying similar binding affinity to the hybridoma-derived AGS-PSCA antibody [1]. AGS-1C4D4 significantly inhibits established pancreatic tumor growth and metastasis in orthotopic HPAC xenograft models when combined with Gemcitabine (), and also significantly inhibits pancreatic tumor formation, local invasion, and distant metastasis in the same orthotopic xenograft model [1].
Purity:
>95% purity as determined by SDS-PAGE.
Endotoxin Level:
< 10 EU/mg
Formulation:
0.01M PBS pH 7.4
State of Matter:
Liquid
Regulatory Status:
For research use only. Not suitable for clinical or therapeutic use.
Product Preparation:
Protein A/G purified from cell culture supernatant.
Storage and Handling:
Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
