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APC Anti-Mouse CD115 Antibody [AFS98] (AGEL1367)

Datasheet MSDS
SKU AGEL1367
Product Type Antibody
Antibody Type Monoclonal Antibody
Reactivity Mouse
Applications FC
€85 - €219

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Description

system_update_altDatasheetsystem_update_altMSDS

APC Anti-Mouse CD115 Antibody [AFS98]

The Mouse CD115 Monoclonal Antibody (APC Conjugated) AFS98 (AGEL1367) is a high-quality antibody specifically designed for research involving CD115, a cell surface receptor essential for the differentiation, survival, and function of macrophages. This monoclonal antibody, generated against mouse samples, is conjugated with APC for easy detection and analysis in flow cytometry and other fluorescence-based assays.CD115, also known as CSF-1 receptor, is a key regulator of the mononuclear phagocyte system, playing a crucial role in immune responses, tissue homeostasis, and inflammation. Understanding the expression and activity of CD115 is paramount in studying macrophage biology, immune cell development, and inflammatory disorders.

This antibody enables precise detection of CD115 expression on various cell types, making it invaluable for immunology, oncology, and inflammatory disease research.With its high specificity and sensitivity, the Mouse CD115 Monoclonal Antibody (APC Conjugated) AFS98 (AGEL1367) provides researchers with a powerful tool to investigate the role of CD115 in diverse biological processes and disease states. Its reliable performance and compatibility with flow cytometry make it a valuable asset in advancing our understanding of immune regulation and macrophage function.

Product Title:APC Anti-Mouse CD115 Antibody [AFS98]
SKU:AGEL1367
Size:50 Tests, 100 Tests, 200 Tests
Clone No:AFS98
Synonyms:Macrophage colony-stimulating factor 1 receptor;CSF-1 receptor (EC:2.7.10.1);CSF-1-R;CSF-1R;M-CSF-R;Proto-oncogene c-Fms;CD115;Csf1r;Csfmr;Fms;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2a, κ
Isotype Control:APC Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:APC
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:P09581
Gene ID:12978
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CSF-1R, also known as CD115 and M-CSFR, is a single-pass type I membrane protein and member of the platelet-derived growth factor receptor family. This c-fms (Fms proto-oncogene) gene product's natural ligands include M-CSF and IL-34. Structural studies of CD115 have described an Ig-like extracellular domain, a transmembrane domain, an intracellular juxtamembrane domain, a split tyrosine kinase domain, and a C-terminal tail receptor. Receptor activation induces homodimerization in addition to phosphorylation and ubiquitination of intracellular residues. CD115 directly influences tissue macrophage and osteoclast differentiation and proliferation. It is expressed on monocytes/macrophages, peritoneal exudate cells, plasmacytoid and conventional dendritic cells, and osteoclasts.
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