Description

Biotin Anti-Mouse CD11c Antibody [N418]

The Biotin-Conjugated Mouse CD11c Monoclonal Antibody (N418) is expertly designed for research involving CD11c, a critical cell surface molecule expressed on dendritic cells and other immune cells, crucial for antigen presentation and immune response activation. This monoclonal antibody, produced in mice, is highly specific to mouse CD11c and is validated for use in flow cytometry and immunohistochemistry applications. The biotin conjugation enhances detection and quantification through various biotin-avidin/streptavidin-based assay systems, providing precise and reliable results.CD11c, a component of the integrin complex, plays a pivotal role in the immune system by aiding in the capture and presentation of antigens to T cells, thus initiating immune responses. Its importance in immune regulation makes it a valuable target for research into autoimmune disorders, infectious diseases, and cancer.

The Biotin-Conjugated Mouse CD11c Monoclonal Antibody (N418) is an indispensable tool for researchers aiming to investigate dendritic cell function and develop therapies that modulate immune activity.By facilitating accurate and sensitive detection of CD11c, this antibody supports comprehensive studies of immune response pathways, contributing to the development of novel therapeutic strategies for autoimmune diseases, chronic inflammatory conditions, and immune-related disorders. Understanding the activity of CD11c is crucial for creating innovative immunotherapies that leverage or modulate antigen presentation in various disease contexts. This antibody is essential for advancing immunology and cancer research.

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Product Title:	Biotin Anti-Mouse CD11c Antibody [N418]
SKU:	AGEL0027
Size:	25µg, 100µg
Clone No:	N418
Synonyms:	Integrin alpha-X;Itgax;CD11 antigen-like family member C;Leukocyte adhesion receptor p150+95;CD11c;
Host Species:	Armenian Hamster
Reactivity:	Mouse
Application:	FCM

Isotype:	Armenian Hamster IgG
Isotype Control:	Biotin Armenian Hamster IgG Isotype Control[PIP]
Form:	Liquid
Conjugation:	Biotin
Recommended Use:	Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

Swissprot:	Q9QXH4
Gene ID:	16411
Storage Buffer:	Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:	Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:	CD11c is a 150 kD glycoprotein also known as αX integrin, CR4, and p150. CD11c forms a αXβ2 heterodimer with β2 integrin (CD18). It is primarily expressed on dendritic cells, NK cells, a subset of intestinal intraepithelial lymphocytes (IEL), and some activated T cells. The αXβ2 integrin plays an important role in cell-cell contact by binding its ligands: iC3b, fibrinogen and CD54.

Biotin Anti-Mouse CD11c Antibody [N418] (AGEL0027)

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Description