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PE/Cyanine5 Anti-Mouse CD162 Antibody [4RA10] (AGEL0850)

Datasheet MSDS
SKU AGEL0850
Product Type Antibody
Antibody Type Monoclonal Antibody
Reactivity Mouse
Applications FC
$132 - $363

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Description

system_update_altDatasheetsystem_update_altMSDS

PE/Cyanine5 Anti-Mouse CD162 Antibody [4RA10]

The Mouse CD162 Monoclonal Antibody PE-Cyanine5 Conjugated (4RA10) is a powerful tool for researchers studying immune responses and cell surface molecules. This antibody, conjugated with PE-Cyanine5, specifically targets CD162, a cell adhesion molecule involved in immune cell interactions and inflammatory processes. With high reactivity towards mouse samples, this antibody is optimized for flow cytometry applications, allowing for precise detection and analysis of CD162 expression in various cell populations. Its monoclonal nature ensures consistency and specificity in binding to the CD162 protein, making it an essential reagent for immunology and inflammation research.

CD162, also known as SELPLG, plays a crucial role in leukocyte adhesion and migration, contributing to immune surveillance and inflammatory responses. Studies on CD162 can provide insights into mechanisms underlying immune cell recruitment and activation, with implications for immune-mediated diseases such as inflammation, infection, and autoimmune disorders.By utilizing the Mouse CD162 Monoclonal Antibody PE-Cyanine5 Conjugated (4RA10), researchers can delve deeper into understanding the intricate workings of immune cell interactions and develop new strategies for modulating immune responses in various pathophysiological conditions.

Product Title:PE/Cyanine5 Anti-Mouse CD162 Antibody [4RA10]
SKU:AGEL0850
Size:25µg, 100µg
Clone No:4RA10
Synonyms:P-selectin glycoprotein ligand 1;Selplg;PSGL-1;Selectin P ligand;CD162;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG1, κ
Isotype Control:PE/Cyanine5 Rat IgG1, κ Isotype Control[HRPN]
Form:Liquid
Conjugation:PE/Cyanine 5
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:Q62170
Gene ID:20345
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:The 4RA10 antibody reacts with the N-terminal functional peptide of CD162 (P-selectin glycoprotein ligand-1, PSGL-1), encoded by the Selpl gene. PSGL-1 is expressed on the cell surface as a homodimer of approximately 230 kDa. In the mouse, Selpl mRNA is detected in most tissues, with high levels found in hematopoietic cells, brain, and adipose tissue. Flow cytometric analyses have revealed CD162 expression on bone marrow-derived mast and dendritic cells, splenic leukocytes, platelets, peripheral blood neutrophils, and neutrophil and T-cell lines. PSGL-1 is a ligand for P-selectin (CD62P) and is involved in leukocyte rolling, the migration of leukocytes into inflamed tissues, and responses to vascular injury. It is a sialomucin that must be specifically sialylated, fucosylated, and sulfated to bind P-selectin. There is also evidence that other ligands for PSGL-1 and CD62P may exist. 4RA10 mAb is reported to block the binding of mouse leukocytes to CD62P and CD62L.
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